Pub. Date : 2014 Jan
PMID : 24035379
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine, an alpha-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion. | Dexmedetomidine | adrenergic receptor, alpha 2a | Mus musculus |
| 2 | OBJECTIVE: Dexmedetomidine, an alpha-2a adrenergic agonist, given pre- and postoperatively was previously shown to attenuate neuronal injury in a murine model of spinal cord ischemia-reperfusion. | Dexmedetomidine | adrenergic receptor, alpha 2a | Mus musculus |
| 3 | CONCLUSIONS: Pretreatment with the alpha-2a agonist dexmedetomidine preserved neurologic function and attenuated neuronal injury following thoracic aortic occlusion in mice. | Dexmedetomidine | adrenergic receptor, alpha 2a | Mus musculus |
| 4 | Thus, alpha-2a receptor agonism-induced CREB phosphorylation and contributes to dexmedetomidine"s protective mechanism in the spinal cord following ischemia. | Dexmedetomidine | adrenergic receptor, alpha 2a | Mus musculus |