| 1 |
34383332 | Dispersion and utilization of lipid droplets mediates respiratory syncytial virus-induced airway hyperresponsiveness. | 2022 Jan |
1 |
| 2 |
35051813 | Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold. | 2022 Feb 15 |
1 |
| 3 |
33100202 | Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus. | 2021 |
1 |
| 4 |
33495605 | Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges. | 2021 Mar |
3 |
| 5 |
33897464 | Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease. | 2021 |
2 |
| 6 |
33924402 | Effect of Obesity on the Expression of Nutrient Receptors and Satiety Hormones in the Human Colon. | 2021 Apr 13 |
1 |
| 7 |
31649307 | A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40. | 2020 Jun |
1 |
| 8 |
31756367 | Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion. | 2020 Mar |
1 |
| 9 |
31846762 | Free Fatty Acid Receptors as new potential therapeutic target in inflammatory bowel diseases. | 2020 Feb |
2 |
| 10 |
31911242 | Identification and characterization of fragment binding sites for allosteric ligand design using the site identification by ligand competitive saturation hotspots approach (SILCS-Hotspots). | 2020 Apr |
1 |
| 11 |
31951921 | Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands. | 2020 Apr |
2 |
| 12 |
33133087 | The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. | 2020 |
1 |
| 13 |
33256729 | FFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells. | 2020 Nov 30 |
1 |
| 14 |
30597558 | Upregulation of free fatty acid receptors in periodontal tissues of patients with metabolic syndrome and periodontitis. | 2019 Aug |
1 |
| 15 |
30655940 | Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination. | 2019 Jan 10 |
1 |
| 16 |
31109791 | Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs. | 2019 Jul 15 |
1 |
| 17 |
31310579 | Metabolic control via nutrient-sensing mechanisms: role of taste receptors and the gut-brain neuroendocrine axis. | 2019 Oct 1 |
1 |
| 18 |
28117025 | Recent Advances in Development of GPR40 Modulators (FFA1/FFAR1): An Emerging Target for Type 2 Diabetes. | 2017 |
1 |
| 19 |
26974308 | Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. | 2016 Apr |
1 |
| 20 |
26974599 | Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry. | 2016 Apr 5 |
1 |
| 21 |
27607913 | Development of novel ligands for peptide GPCRs. | 2016 Dec |
1 |
| 22 |
27749056 | The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). | 2016 Dec 22 |
4 |
| 23 |
25615413 | Dual effects of the non-esterified fatty acid receptor 'GPR40' for human health. | 2015 Apr |
2 |
| 24 |
25092426 | Activation of G-protein-coupled receptor 40 attenuates the cisplatin-induced apoptosis of human renal proximal tubule epithelial cells. | 2014 Oct |
2 |
| 25 |
25161890 | Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans. | 2014 Sep |
1 |
| 26 |
23357262 | [Research progress in G protein-coupled receptor 40]. | 2013 Jan |
1 |
| 27 |
23831422 | Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. | 2013 Oct 10 |
1 |
| 28 |
23882043 | Activation of GPR40 as a therapeutic target for the treatment of type 2 diabetes. | 2013 Aug |
4 |
| 29 |
24051395 | Modulating GPR40: therapeutic promise and potential in diabetes. | 2013 Dec |
1 |
| 30 |
22308370 | Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. | 2012 Feb 14 |
1 |
| 31 |
22374408 | TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. | 2012 Apr 14 |
3 |
| 32 |
22490067 | Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent. | 2012 Apr 26 |
1 |
| 33 |
23060857 | Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets. | 2012 |
1 |
| 34 |
21570468 | Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. | 2011 Aug |
2 |
| 35 |
21606626 | Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: implication of fatty acid-binding proteins (FABP) and G protein-coupled receptor 40 (GPR40) in adult neurogenesis. | 2011 |
1 |
| 36 |
19758793 | G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: the role of type 2 diabetes and fatty acids. | 2010 Jan |
2 |
| 37 |
19460454 | Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. | 2009 Sep |
1 |
| 38 |
19660440 | G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. | 2009 Dec 15 |
1 |
| 39 |
19817784 | Lipid receptors and islet function: therapeutic implications? | 2009 Nov |
1 |
| 40 |
18481958 | Regulation of the GPR40 locus: towards a molecular understanding. | 2008 Jun |
1 |
| 41 |
19009545 | Fatty acid binding receptors and their physiological role in type 2 diabetes. | 2008 Dec |
1 |
| 42 |
17200419 | Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist. | 2007 Apr |
3 |
| 43 |
17583366 | Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys. | 2007 Aug |
1 |
| 44 |
17052194 | The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing. | 2006 Nov |
1 |
| 45 |
15684720 | A family of fatty acid binding receptors. | 2005 Jan |
2 |
| 46 |
15695516 | Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. | 2005 Apr 8 |
1 |
| 47 |
15736105 | GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men. | 2005 Mar |
2 |
| 48 |
16044321 | Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. | 2005 Nov |
4 |
| 49 |
16081037 | Role of GPR40 in fatty acid action on the beta cell line INS-1E. | 2005 Sep 16 |
1 |