PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33924402-10 2021 CONCLUSIONS: While expression of medium/long chain fatty acid receptor GPR40 was increased in the sigmoid colon of the high BMI group, expression of other nutrient sensing GPCRs, and expression profiles of EECs involved in peripheral mechanisms of appetite regulation were unchanged. Fatty Acids 51-61 free fatty acid receptor 1 Homo sapiens 71-76 33495605-3 2021 Among them are GPCRs specific for free fatty acid ligands (lipid GPCRs), including free fatty acid receptor 1 (FFA1, otherwise known as GPR40), FFA2 (GPR43), FFA3 (GPR41) and FFA4 (GPR120), as well as the lipid metabolite binding glucose-dependent insulinotropic receptor (GPR119). Fatty Acids 39-49 free fatty acid receptor 1 Homo sapiens 83-109 33897464-4 2021 Medium- and long-chain fatty acids (6-12 and 13-21 carbon, respectively) target both FFAR1/GPR40 and FFAR4/GPR120. Fatty Acids 23-34 free fatty acid receptor 1 Homo sapiens 85-90 33897464-4 2021 Medium- and long-chain fatty acids (6-12 and 13-21 carbon, respectively) target both FFAR1/GPR40 and FFAR4/GPR120. Fatty Acids 23-34 free fatty acid receptor 1 Homo sapiens 91-96 33495605-3 2021 Among them are GPCRs specific for free fatty acid ligands (lipid GPCRs), including free fatty acid receptor 1 (FFA1, otherwise known as GPR40), FFA2 (GPR43), FFA3 (GPR41) and FFA4 (GPR120), as well as the lipid metabolite binding glucose-dependent insulinotropic receptor (GPR119). Fatty Acids 39-49 free fatty acid receptor 1 Homo sapiens 111-115 33495605-3 2021 Among them are GPCRs specific for free fatty acid ligands (lipid GPCRs), including free fatty acid receptor 1 (FFA1, otherwise known as GPR40), FFA2 (GPR43), FFA3 (GPR41) and FFA4 (GPR120), as well as the lipid metabolite binding glucose-dependent insulinotropic receptor (GPR119). Fatty Acids 39-49 free fatty acid receptor 1 Homo sapiens 136-141 33100202-9 2021 Some natural/plant derived compounds including fatty acids, sesquiterpenes, phenolic compounds, anthocyanins, isoquinoline and indole alkaloids were also reported as potent FFAR1 agonists. Fatty Acids 47-58 free fatty acid receptor 1 Homo sapiens 173-178 33256729-1 2020 BACKGROUND: Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airway smooth muscle (HASM) cell proliferation and shortening. Fatty Acids 31-41 free fatty acid receptor 1 Homo sapiens 53-58 33133087-1 2020 G-protein-coupled receptor 40 (GPR40) is known to play a role in the regulation of fatty acids, insulin secretion, and inflammation. Fatty Acids 83-94 free fatty acid receptor 1 Homo sapiens 31-36 31649307-0 2020 A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40. Fatty Acids 125-135 free fatty acid receptor 1 Homo sapiens 145-150 31911242-7 2020 The identified sites are shown to recapitulate the location of known drug-like molecules in both allosteric and orthosteric binding sites on seven proteins including the androgen receptor, the CDK2 and Erk5 kinases, PTP1B phosphatase and three GPCRs; the beta2-adrenergic, GPR40 fatty-acid binding and M2-muscarinic receptors. Fatty Acids 279-289 free fatty acid receptor 1 Homo sapiens 273-278 31951921-2 2020 Here, we focus on the succinate receptor SUCNR1/GPR91 and the long chain fatty acid receptor FFAR1/GPR40, for which 3D structural information is available. Fatty Acids 73-83 free fatty acid receptor 1 Homo sapiens 93-98 31951921-2 2020 Here, we focus on the succinate receptor SUCNR1/GPR91 and the long chain fatty acid receptor FFAR1/GPR40, for which 3D structural information is available. Fatty Acids 73-83 free fatty acid receptor 1 Homo sapiens 99-104 31756367-5 2020 We review the evidence for an important role of sodium-coupled glucose uptake through SGLT1 for carbohydrate sensing, of free-fatty acid receptors FFAR1/FFAR4 and the monoacyl-glycerol sensing receptor GPR119 for lipid detection, of the calcium-sensing receptor CASR and GPR142 for protein sensing, and additional modulation by neurotransmitters such as somatostatin and galanin. Fatty Acids 126-136 free fatty acid receptor 1 Homo sapiens 147-152 31109791-2 2019 When activated by fatty acids, GPR40 elicits increased insulin secretion from islet beta-cells only in the presence of elevated glucose levels. Fatty Acids 18-29 free fatty acid receptor 1 Homo sapiens 31-36 31846762-1 2020 Family of Free Fatty Acid Receptors (FFARs), specific G protein-coupled receptors comprises of four members: FFAR1-4, where each responds to different chain length of fatty acids (FAs). Fatty Acids 15-25 free fatty acid receptor 1 Homo sapiens 109-116 31846762-1 2020 Family of Free Fatty Acid Receptors (FFARs), specific G protein-coupled receptors comprises of four members: FFAR1-4, where each responds to different chain length of fatty acids (FAs). Fatty Acids 167-178 free fatty acid receptor 1 Homo sapiens 109-116 31310579-7 2019 Furthermore, several GPCRs have been implicated in fatty acid sensing: GPR40 and GPR120 respond to medium- and long-chain fatty acids, GPR41 and GPR43 to short-chain fatty acids, and GPR119 to endogenous lipid derivatives. Fatty Acids 51-61 free fatty acid receptor 1 Homo sapiens 71-76 30597558-5 2019 We also determined the effect of SFA and LPS on GPR40 and CD36 expression in vitro. Fatty Acids 33-36 free fatty acid receptor 1 Homo sapiens 48-53 30655940-1 2019 GPR40 is a G-protein-coupled receptor which mediates fatty acid-induced glucose-stimulated insulin secretion from pancreatic beta cells and incretion release from enteroendocrine cells of the small intestine. Fatty Acids 53-63 free fatty acid receptor 1 Homo sapiens 0-5 28117025-2 2017 Since its deorphanization in 2003, G-protein-coupled receptor GPR40 has emerged as a potential target for type II diabetes because it has been hypothesized to participate in the adverse effects of chronic fatty acid exposure on function of beta-cell. Fatty Acids 205-215 free fatty acid receptor 1 Homo sapiens 62-67 27607913-3 2016 In addition, fatty acids GPCRs are thought to have an increasing role in regulating peptide secretions namely short fatty acids GPCR (GPR41, GPR43), medium chain fatty acid GPCR (GPR84), long chain fatty acid GPCR (GPR40, GPR120) and cannabinoid-like GPCR (GPR55, GPR119). Fatty Acids 13-24 free fatty acid receptor 1 Homo sapiens 215-220 27749056-1 2016 The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence of elevated glucose levels. Fatty Acids 170-181 free fatty acid receptor 1 Homo sapiens 4-33 27749056-1 2016 The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence of elevated glucose levels. Fatty Acids 170-181 free fatty acid receptor 1 Homo sapiens 35-40 27749056-1 2016 The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence of elevated glucose levels. Fatty Acids 170-181 free fatty acid receptor 1 Homo sapiens 56-82 27749056-1 2016 The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence of elevated glucose levels. Fatty Acids 170-181 free fatty acid receptor 1 Homo sapiens 84-89 26974308-4 2016 Moreover, we identify a lipid sensor, free fatty acid receptor 1 (Ffar1), that curbs glucose uptake when fatty acids are available. Fatty Acids 105-116 free fatty acid receptor 1 Homo sapiens 66-71 26974599-0 2016 Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry. Fatty Acids 44-55 free fatty acid receptor 1 Homo sapiens 67-96 25615413-1 2015 G protein-coupled receptor 40 (GPR40), a receptor for diverse non-esterified fatty acids, is expressed predominantly in the wide variety of neurons of the central nervous system and beta-cells in the pancreatic islets. Fatty Acids 77-88 free fatty acid receptor 1 Homo sapiens 0-29 25615413-1 2015 G protein-coupled receptor 40 (GPR40), a receptor for diverse non-esterified fatty acids, is expressed predominantly in the wide variety of neurons of the central nervous system and beta-cells in the pancreatic islets. Fatty Acids 77-88 free fatty acid receptor 1 Homo sapiens 31-36 25092426-1 2014 G-protein-coupled receptor 40 (GPR40) is known to play a role in the regulation of fatty acids, insulin secretion and inflammation. Fatty Acids 83-94 free fatty acid receptor 1 Homo sapiens 0-29 25092426-1 2014 G-protein-coupled receptor 40 (GPR40) is known to play a role in the regulation of fatty acids, insulin secretion and inflammation. Fatty Acids 83-94 free fatty acid receptor 1 Homo sapiens 31-36 22490067-0 2012 Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent. Fatty Acids 85-95 free fatty acid receptor 1 Homo sapiens 122-151 25161890-1 2014 Genetic variation in FFAR1 modulates insulin secretion dependent on non-esterified fatty acid (NEFA) concentrations. Fatty Acids 72-93 free fatty acid receptor 1 Homo sapiens 21-26 24051395-1 2013 The class A G-protein-coupled receptor GPR40 is predominantly expressed in pancreatic beta cells and plays a major part in fatty acid amplification of glucose-induced insulin secretion. Fatty Acids 123-133 free fatty acid receptor 1 Homo sapiens 39-44 23831422-6 2013 In human subjects, two-alternative forced choice (2-AFC) tests, triangle tests and sensory profiling showed that non fatty acid agonists of GPR40 dissolved in water are detected in sip and spit tests and elicit a taste similar to that of linoleic acid, whereas 2-AFC tests showed that two agonists of GPR120 in water are not perceived fattier than water alone. Fatty Acids 117-127 free fatty acid receptor 1 Homo sapiens 140-145 23882043-3 2013 The G-protein-coupled receptor 40 (GPR40), also known as free fatty acid receptor 1 (we will use GPR40 in this review), has emerged as an important component in the fatty acid augmentation of insulin secretion. Fatty Acids 62-72 free fatty acid receptor 1 Homo sapiens 4-33 23882043-3 2013 The G-protein-coupled receptor 40 (GPR40), also known as free fatty acid receptor 1 (we will use GPR40 in this review), has emerged as an important component in the fatty acid augmentation of insulin secretion. Fatty Acids 62-72 free fatty acid receptor 1 Homo sapiens 35-40 23882043-3 2013 The G-protein-coupled receptor 40 (GPR40), also known as free fatty acid receptor 1 (we will use GPR40 in this review), has emerged as an important component in the fatty acid augmentation of insulin secretion. Fatty Acids 62-72 free fatty acid receptor 1 Homo sapiens 97-102 23882043-5 2013 Synthetic small-molecule agonists of GPR40 enhance insulin secretion in a glucose-dependent manner in vitro and in vivo with a mechanism similar to that found with fatty acids. Fatty Acids 164-175 free fatty acid receptor 1 Homo sapiens 37-42 23357262-4 2013 In b-cell, intracellular calcium concentration elevates when GPR40 is binding to fatty acid, thereby promoting the release of insulin. Fatty Acids 81-91 free fatty acid receptor 1 Homo sapiens 61-66 23060857-1 2012 The deorphanization of the free fatty acid (FFA) receptors FFA1 (GPR40), FFA2 (GPR43), FFA3 (GPR41), GPR84, and GPR120 has made clear that the body is capable of recognizing and responding directly to nonesterified fatty acid of virtually any chain length. Fatty Acids 32-42 free fatty acid receptor 1 Homo sapiens 65-70 22374408-1 2012 BACKGROUND: Activation of free fatty acid receptor 1 (FFAR1; also known as G-protein-coupled receptor 40) by fatty acids stimulated glucose-dependent beta-cell insulin secretion in preclinical models. Fatty Acids 109-120 free fatty acid receptor 1 Homo sapiens 26-52 22374408-1 2012 BACKGROUND: Activation of free fatty acid receptor 1 (FFAR1; also known as G-protein-coupled receptor 40) by fatty acids stimulated glucose-dependent beta-cell insulin secretion in preclinical models. Fatty Acids 109-120 free fatty acid receptor 1 Homo sapiens 54-59 22374408-1 2012 BACKGROUND: Activation of free fatty acid receptor 1 (FFAR1; also known as G-protein-coupled receptor 40) by fatty acids stimulated glucose-dependent beta-cell insulin secretion in preclinical models. Fatty Acids 109-120 free fatty acid receptor 1 Homo sapiens 75-104 22308370-1 2012 The G protein-coupled free fatty acid receptor-1 (FFA1/GPR40) plays a major role in the regulation of insulin secretion by fatty acids. Fatty Acids 123-134 free fatty acid receptor 1 Homo sapiens 55-60 21606626-0 2011 Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: implication of fatty acid-binding proteins (FABP) and G protein-coupled receptor 40 (GPR40) in adult neurogenesis. Fatty Acids 60-70 free fatty acid receptor 1 Homo sapiens 184-189 21570468-4 2011 Here, we studied the ability of phytanic acid and pristanic acid to activate the free fatty acid receptor GPR40, a G-protein-coupled receptor, which was described to be involved in the Ca2+ signaling of fatty acids. Fatty Acids 203-214 free fatty acid receptor 1 Homo sapiens 106-111 21570468-7 2011 Furthermore, we demonstrate that the GPR40 activation might be due to an interaction of the carboxylate moiety of fatty acids with the receptor. Fatty Acids 114-125 free fatty acid receptor 1 Homo sapiens 37-42 17200419-5 2007 After expression of GPR40-Galpha(q) in HEK293 cells and membrane preparation basal binding of [(35)S]GTPgammaSinGalpha(q) immunoprecipitates was high and not elevated substantially by fatty acids. Fatty Acids 184-195 free fatty acid receptor 1 Homo sapiens 20-25 19758793-0 2010 G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: the role of type 2 diabetes and fatty acids. Fatty Acids 128-139 free fatty acid receptor 1 Homo sapiens 0-29 19758793-0 2010 G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: the role of type 2 diabetes and fatty acids. Fatty Acids 128-139 free fatty acid receptor 1 Homo sapiens 31-36 19660440-5 2009 GPR40 has also been proposed as a potential mediator of fatty acid toxicity but this is more controversial. Fatty Acids 56-66 free fatty acid receptor 1 Homo sapiens 0-5 19817784-3 2009 GPR40 was shown to be activated by medium- to long-chain fatty acids (FAs). Fatty Acids 70-73 free fatty acid receptor 1 Homo sapiens 0-5 19460454-1 2009 Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120). Fatty Acids 5-16 free fatty acid receptor 1 Homo sapiens 113-118 19009545-6 2008 However, the receptors through which these fatty acids and lipids act were unknown, until the identification of fatty acid binding receptors: GPR40, GPR41, GPR43, and GPR119. Fatty Acids 43-54 free fatty acid receptor 1 Homo sapiens 142-147 18481958-2 2008 GPR40 functions as a receptor for medium and long-chain fatty acids, and has been implicated in mediating both physiological and pathological effects of fatty acids on beta-cells. Fatty Acids 56-67 free fatty acid receptor 1 Homo sapiens 0-5 17583366-3 2007 While free fatty acid effects on the brain might be related to GPR40 activation, the role of GPR40 in the central nervous system (CNS) is at present not known. Fatty Acids 11-21 free fatty acid receptor 1 Homo sapiens 63-68 17200419-6 2007 However, treatment of membranes with fatty acid-free bovine serum albumin reduced the basal [(35)S]GTPgammaS binding in a concentration-dependent manner and allowed the responsiveness and pharmacology at GPR40 of each of the fatty acids thiazolidinediones and a novel small-molecule agonist to be uncovered. Fatty Acids 37-47 free fatty acid receptor 1 Homo sapiens 204-209 17200419-9 2007 The current studies provide novel insights into the pharmacology of GPR40 and indicate that G protein-coupled receptors which respond to fatty acids, and potentially to other lipid ligands, can be occupied by endogenous agonists before assay and that this may mask the pharmacology of the receptor and may be mistaken for high levels of constitutive activity. Fatty Acids 137-148 free fatty acid receptor 1 Homo sapiens 68-73 15695516-10 2005 The results suggest that GPR40 is implicated in the control of breast cancer cell growth by fatty acids and that GPR40 may provide a link between fat and cancer. Fatty Acids 92-103 free fatty acid receptor 1 Homo sapiens 25-30 17052194-6 2006 GPR40, activated by medium and long-chain fatty acids, has been shown to potentiate insulin secretion at the beta-cell, and has been hypothesized to participate in the detrimental effects of chronic fatty acid exposure on beta-cell function. Fatty Acids 42-52 free fatty acid receptor 1 Homo sapiens 0-5 16044321-0 2005 Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. Fatty Acids 66-76 free fatty acid receptor 1 Homo sapiens 28-35 16044321-2 2005 The recently de-orphanized G-protein coupled receptor, FFA(1)R/GPR40, has been shown to be essential for fatty-acid-stimulated insulin release in MIN6 mouse insulinoma cells. Fatty Acids 105-115 free fatty acid receptor 1 Homo sapiens 55-62 16044321-10 2005 The results demonstrate that FFA(1)R/GPR40 is inhibited by the CPT-1 inhibitor, 2BrP, and confirm that FFA(1)R/GPR40 is indeed necessary, at least in part, for fatty-acid-stimulated insulin release. Fatty Acids 160-170 free fatty acid receptor 1 Homo sapiens 29-36 16044321-10 2005 The results demonstrate that FFA(1)R/GPR40 is inhibited by the CPT-1 inhibitor, 2BrP, and confirm that FFA(1)R/GPR40 is indeed necessary, at least in part, for fatty-acid-stimulated insulin release. Fatty Acids 160-170 free fatty acid receptor 1 Homo sapiens 103-110 16081037-0 2005 Role of GPR40 in fatty acid action on the beta cell line INS-1E. Fatty Acids 17-27 free fatty acid receptor 1 Homo sapiens 8-13 15684720-3 2005 The GPR40 family of receptors, tandemly located on chromosome 19q13.1, exhibit 30-40% homology to one another and diverse tissue distribution, yet all are activated by fatty acids. Fatty Acids 168-179 free fatty acid receptor 1 Homo sapiens 4-9 15736105-2 2005 Recent studies suggest that GPR40 is highly expressed in pancreatic beta cells and insulin-secreting cell lines, and that fatty acids increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion by activating GPR40. Fatty Acids 122-133 free fatty acid receptor 1 Homo sapiens 28-33 15736105-2 2005 Recent studies suggest that GPR40 is highly expressed in pancreatic beta cells and insulin-secreting cell lines, and that fatty acids increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion by activating GPR40. Fatty Acids 122-133 free fatty acid receptor 1 Homo sapiens 242-247 15684720-4 2005 Since agonists of GPR40 are medium to longchain fatty acids and those for GPR41 and 43 are short-chain fatty acids, the family clearly provides an intriguing example of how the ligand specificity, patterns of expression, and function of GPCRs can diverge through evolution. Fatty Acids 48-59 free fatty acid receptor 1 Homo sapiens 18-23 35051813-1 2022 The free fatty acid receptor 1 (FFA1/GPR40) and peroxisome proliferator-activated receptor delta (PPARdelta) have been widely considered as promising targets for type 2 diabetes mellitus (T2DM) due to their respective roles in promoting insulin secretion and improving insulin sensitivity. Fatty Acids 9-19 free fatty acid receptor 1 Homo sapiens 37-42 34383332-7 2022 There was also a decrease in PPARgamma expression and an increase in the fatty acid catabolism gene PPARalpha, causing lipid oxidation, free fatty acid releaseas and an upsurge in IL-1, IL-2, IL-4 and IL-6 expression, which could be abrogated by GPR40 inhibitor. Fatty Acids 73-83 free fatty acid receptor 1 Homo sapiens 246-251