Title : Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40.

Pub. Date : 2011 Aug

PMID : 21570468






2 Functional Relationships(s)
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1 Here, we studied the ability of phytanic acid and pristanic acid to activate the free fatty acid receptor GPR40, a G-protein-coupled receptor, which was described to be involved in the Ca2+ signaling of fatty acids. Fatty Acids free fatty acid receptor 1 Homo sapiens
2 Furthermore, we demonstrate that the GPR40 activation might be due to an interaction of the carboxylate moiety of fatty acids with the receptor. Fatty Acids free fatty acid receptor 1 Homo sapiens