nilotinib

ABL proto-oncogene 1, non-receptor tyrosine kinase ; Homo sapiens







274 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
51 30217442 BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells. 2018 Oct 12 1
52 30705677 NKG2A Down-Regulation by Dasatinib Enhances Natural Killer Cytotoxicity and Accelerates Effective Treatment Responses in Patients With Chronic Myeloid Leukemia. 2018 1
53 31249931 BCR-ABL Tyrosine Kinase Inhibitors: Which Mechanism(s) May Explain the Risk of Thrombosis? 2018 Jan 1
54 27686674 Constitutional t(8;22)(q24;q11.2) that mimics the variant Burkitt-type translocation in Philadelphia chromosome-positive chronic myeloid leukemia. 2017 Feb 1
55 27852118 Risk of arterial and venous occlusive events in chronic myeloid leukemia patients treated with new generation BCR-ABL tyrosine kinase inhibitors: a systematic review and meta-analysis. 2017 Jan 1
56 28224300 Nilotinib first-line therapy in patients with Philadelphia chromosome-negative/BCR-ABL-positive chronic myeloid leukemia in chronic phase: ENEST1st sub-analysis. 2017 Jul 1
57 28349229 MPT0B002, a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells. 2017 Aug 1
58 28601294 The c-Abl inhibitor, nilotinib, as a potential therapeutic agent for chronic cerebellar ataxia. 2017 Aug 15 2
59 28706179 Nilotinib Induced Recurrent Gastric Polyps: Case Report and Review of Literature. 2017 Jul 14 1
60 28757617 Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site. 2017 Nov 1
61 28801986 Persistent detection of alternatively spliced BCR-ABL variant results in a failure to achieve deep molecular response. 2017 Nov 1
62 26479578 In-silico identification of inhibitors against mutated BCR-ABL protein of chronic myeloid leukemia: a virtual screening and molecular dynamics simulation study. 2016 Oct 1
63 26582603 Hyaluronan oligomers sensitize chronic myeloid leukemia cell lines to the effect of Imatinib. 2016 Apr 1
64 26607600 Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML. 2016 Apr 15 1
65 26847385 Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report. 2016 Mar 1
66 27044711 A role for FOXO1 in BCR-ABL1-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemia. 2016 Jul 2
67 27194977 Nilotinib-Induced Keratosis Pilaris. 2016 Jan-Apr 2
68 27293031 Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling. 2016 Jun 13 2
69 27434297 Nilotinib Effects in Parkinson's disease and Dementia with Lewy bodies. 2016 Jul 11 3
70 27583255 Current status of ABL tyrosine kinase inhibitors stop studies for chronic myeloid leukemia. 2016 1
71 27821800 Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia. 2016 Nov 29 2
72 27864817 Surgical resection of recurrent gastrointestinal stromal tumor after interruption of long-term nilotinib therapy. 2016 Dec 1
73 28191543 The third-time chronic myeloid leukemia in lymphoblastic crisis with ABL1 kinase mutation induced by decitabine, dexamethason combined with nilotinib and dasatinib. 2016 Dec 1 1
74 25527332 The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear. 2015 Jan 1
75 25721903 Persistent major molecular response to nilotinib therapy in a patient with chronic myeloid leukemia harboring ABL gene T315I mutation. 2015 1
76 25803821 ABL tyrosine kinase inhibition variable effects on the invasive properties of different triple negative breast cancer cell lines. 2015 1
77 25882987 Nilotinib versus imatinib as first-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trial. 2015 May 1
78 25889792 The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells. 2015 Mar 24 2
79 25900790 Long-term efficacy and safety of nilotinib therapy after imatinib failure in eosinophilic myeloproliferative neoplasm and ETV6-ABL rearrangement. 2015 Aug 1
80 26139550 [Peripheral artery occlusive disease of the lower limbs: Rapid aggravation in a patient taking nilotinib for chronic myeloid leukemia]. 2015 Jul 1
81 26195136 Hybrid pyrimidine alkynyls inhibit the clinically resistance related Bcr-Abl(T315I) mutant. 2015 Sep 1 1
82 26266095 Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis. 2015 1
83 26473951 Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release. 2015 1
84 26622510 Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report. 2015 Oct 3
85 24100660 Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with nilotinib against BCR-ABL-positive leukemia cells involves the ABL kinase domain mutation. 2014 Feb 2
86 24143950 BCR-ABL inhibitors: updates in the management of patients with chronic-phase chronic myeloid leukemia. 2014 Jul 1
87 24258348 Ever-advancing chronic myeloid leukemia treatment. 2014 Feb 1
88 24333114 Nilotinib 300 mg BID as frontline treatment of CML: prospective analysis of the Xpert BCR-ABL monitor system and significance of 3-month molecular response. 2014 Mar 1
89 24412932 c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. 2014 Jun 1 2
90 24651611 Nilotinib enhances the efficacy of conventional chemotherapeutic drugs in CD34⁺CD38⁻ stem cells and ABC transporter overexpressing leukemia cells. 2014 Mar 19 2
91 24662807 Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans. 2014 Jul 1
92 24756785 Nilotinib. 2014 1
93 24786396 The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. 2014 May 2 1
94 24789045 Geminin overexpression promotes imatinib sensitive breast cancer: a novel treatment approach for aggressive breast cancers, including a subset of triple negative. 2014 1
95 24847647 New resistance mechanisms for small molecule kinase inhibitors of Abl kinase. 2014 Mar 1
96 24865254 Pharmacophore modeling of nilotinib as an inhibitor of ATP-binding cassette drug transporters and BCR-ABL kinase using a three-dimensional quantitative structure-activity relationship approach. 2014 Jul 7 4
97 25006277 Importance of early and deeper responses to long-term survival in CML patients: Implications of BCR-ABL testing in management of CML in Indian setting. 2014 Jan 1
98 25025064 Efficacy and pharmacologic data of second-generation tyrosine kinase inhibitor nilotinib in BCR-ABL-positive leukemia patients with central nervous system relapse after allogeneic stem cell transplantation. 2014 3
99 25038611 In vitro testing of drug combinations employing nilotinib and alkylating agents with regard to pretransplant conditioning treatment of advanced-phase chronic myeloid leukemia. 2014 Aug 1
100 25116401 Nilotinib in combination with carboplatin and paclitaxel is a candidate for ovarian cancer treatment. 2014 1