Sodium

sodium channel, voltage-gated, type I, alpha ; Mus musculus







37 Article(s)
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1 34843701 Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. 2022 Jan 15 2
2 34875285 Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome. 2022 Mar 1 1
3 34980259 Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K). 2022 Jan 3 2
4 35212623 Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome. 2022 Feb 25 2
5 35256591 mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a. 2022 Mar 8 2
6 35370551 Functional Investigation of a Neuronal Microcircuit in the CA1 Area of the Hippocampus Reveals Synaptic Dysfunction in Dravet Syndrome Mice. 2022 2
7 35435735 Cell-Selective Adeno-Associated Virus-Mediated SCN1A Gene Regulation Therapy Rescues Mortality and Seizure Phenotypes in a Dravet Syndrome Mouse Model and Is Well Tolerated in Nonhuman Primates. 2022 Jun 4
8 33234612 Impaired θ-γ Coupling Indicates Inhibitory Dysfunction and Seizure Risk in a Dravet Syndrome Mouse Model. 2021 Jan 20 3
9 33411788 Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy. 2021 Jan 2
10 33436636 Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition. 2021 Jan 12 1
11 33651714 Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models. 2021 Apr 15 1
12 33658306 Interneuron Dysfunction in a New Mouse Model of SCN1A GEFS. 2021 Mar-Apr 1
13 33855971 Epilepsy channelopathies go neddy: stabilizing NaV1.1 channels by neddylation. 2021 Apr 15 2
14 34308420 Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome. 2021 2
15 34324871 Clonazepam attenuates neurobehavioral abnormalities in offspring exposed to maternal immune activation by enhancing GABAergic neurotransmission. 2021 Oct 2
16 31607539 dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice. 2020 Jan 8 1
17 31830809 Sexually Divergent Mortality and Partial Phenotypic Rescue After Gene Therapy in a Mouse Model of Dravet Syndrome. 2020 Mar 2
18 31880072 First FHM3 mouse model shows spontaneous cortical spreading depolarizations. 2020 Jan 1
19 32394465 A 5-HT1D -receptor agonist protects Dravet syndrome mice from seizure and early death. 2020 Nov 2
20 32848094 Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. 2020 Aug 26 1
21 33584198 Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments. 2020 1
22 31578435 Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation. 2019 Oct 2 2
23 31758544 Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice. 2019 Dec 1
24 28987817 The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice. 2018 Jan 1 1
25 29875317 NaV1.1 inhibition can reduce visceral hypersensitivity. 2018 Jun 7 1
26 29956586 Nonmuscle myosin II isoforms interact with sodium channel alpha subunits. 2018 Jan-Dec 1
27 30104343 A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome. 2018 Sep 5 1
28 28490751 Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome. 2017 May 10 1
29 26819275 Unaltered Network Activity and Interneuronal Firing During Spontaneous Cortical Dynamics In Vivo in a Mouse Model of Severe Myoclonic Epilepsy of Infancy. 2016 Apr 2
30 22260870 Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels. 2012 Mar 29 1
31 22705271 Dravet syndrome: the main issues. 2012 Sep 1
32 22787629 Sodium Channel Mutations and Epilepsy 2012 1
33 21463282 Insights into pathophysiology and therapy from a mouse model of Dravet syndrome. 2011 Apr 1
34 20194124 NaV1.1 channels and epilepsy. 2010 Jun 1 1
35 17928448 Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. 2007 Oct 10 2
36 16921370 Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. 2006 Sep 2
37 14715935 Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin. 2004 Jan 7 1