Title : Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome.

Pub. Date : 2020 Aug 26

PMID : 32848094






1 Functional Relationships(s)
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1 Dravet syndrome (DS) is an intractable developmental and epileptic encephalopathy caused largely by de novo variants in the SCN1A gene, resulting in haploinsufficiency of the voltage-gated sodium channel alpha subunit NaV1.1. Sodium sodium channel, voltage-gated, type I, alpha Mus musculus