Pub. Date : 2021 Jan 20
PMID : 33234612
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dysfunction of NaV1.1 sodium channels, which are chiefly expressed in inhibitory interneurons, explains the epileptic phenotype. | Sodium | sodium channel, voltage-gated, type I, alpha | Mus musculus |
| 2 | Locally disrupting NaV1.1 expression in the hippocampus or cortex yielded early attenuation of theta-gamma coupling, which in the hippocampus associated with fast ripples, and which was replicated in a computational model when voltage-gated sodium currents were impaired in basket cells. | Sodium | sodium channel, voltage-gated, type I, alpha | Mus musculus |
| 3 | In the present work we show that decreased theta-gamma coupling precedes and associates with seizure activity in a DS mouse model, which could be replicated by brain region-specific ablation of NaV1.1, a sodium channel affected in the majority of DS patients. | Sodium | sodium channel, voltage-gated, type I, alpha | Mus musculus |