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33581555 | Medicinal chemistry strategies for the development of phosphodiesterase 10A (PDE10A) inhibitors - An update of recent progress. | 2021 Mar 15 |
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33658076 | Structure-based identification of dual ligands at the A2AR and PDE10A with anti-proliferative effects in lung cancer cell-lines. | 2021 Mar 3 |
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33914237 | Papaverine, a Phosphodiesterase 10A Inhibitor, Ameliorates Quinolinic Acid-Induced Synaptotoxicity in Human Cortical Neurons. | 2021 Aug |
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34671065 | Dynamic FRET-FLIM based screening of signal transduction pathways. | 2021 Oct 20 |
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34735298 | Abstract MP265: The Role Of Phosphodiesterase 10a In Tumor Growth And Doxorubicin-induced Cardiotoxicity. | 2021 Sep 3 |
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34907481 | Selectivity mechanism of phosphodiesterase isoform inhibitor through in silico investigations. | 2021 Dec 14 |
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31119377 | Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging study. | 2020 Jun |
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31801360 | A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction. | 2020 Jan 21 |
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31874060 | Phosphodiesterase 10 (PDE10) inhibitors: an updated patent review (2014-present). | 2020 Feb |
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33551724 | PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action? | 2020 |
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30091414 | Advances in Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 1: Overview of the Chemical and Biological Research. | 2019 |
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30951862 | PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders. | 2019 Aug |
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31404565 | Antipsychotic-like effects of a novel phosphodiesterase 10A inhibitor T-251 in rodents. | 2019 Oct |
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29130591 | Familial choreoathetosis due to novel heterozygous mutation in PDE10A. | 2018 Jan |
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29223715 | Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates. | 2018 Feb |
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29508924 | A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys. | 2018 May |
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30345538 | PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology. | 2018 Dec |
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28439226 | The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities. | 2017 |
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28462841 | Design and optimization of purine derivatives as in vivo active PDE10A inhibitors. | 2017 Jul 1 |
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28569061 | Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR. | 2017 Jun 26 |
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29290010 | Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases. | 2017 Dec 30 |
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26713600 | β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG. | 2016 Feb 2 |
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27058447 | De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions. | 2016 Apr 7 |
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27539962 | Effects of a novel phosphodiesterase 10A inhibitor in non-human primates: A therapeutic approach for schizophrenia with improved side effect profile. | 2016 Nov |
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25159072 | Emerging biology of PDE10A. | 2015 |
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25891816 | Development of a series of novel carbon-11 labeled PDE10A inhibitors. | 2015 May 15 |
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26095589 | Phosphodiesterase regulation of alcohol drinking in rodents. | 2015 Dec |
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26198591 | Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease. | 2015 Oct |
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26210536 | Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson's disease. | 2015 Oct |
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24898025 | In vivo assessment and dosimetry of 2 novel PDE10A PET radiotracers in humans: 18F-MNI-659 and 18F-MNI-654. | 2014 Aug |
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25295858 | Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment. | 2014 Dec 19 |
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25297556 | Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity. | 2014 Nov |
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23160998 | Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging. | 2013 Jan |
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23354020 | Inhibition mechanism exploration of quinoline derivatives as PDE10A inhibitors by in silico analysis. | 2013 Mar |
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23691025 | HPRT-deficiency dysregulates cAMP-PKA signaling and phosphodiesterase 10A expression: mechanistic insight and potential target for Lesch-Nyhan Disease? | 2013 |
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21355834 | PDE10A inhibitors: novel therapeutic drugs for schizophrenia. | 2011 |
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21695637 | Structural insight into the substrate specificity of phosphodiesterases. | 2011 |
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21886636 | Identification of new signaling components in the sensory epithelium of human saccule. | 2011 |
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21931705 | Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization. | 2011 |
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20493887 | Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues. | 2010 Nov |
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20716858 | Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: biochemical and behavioral profiles of phosphodiesterase inhibition in dopaminergic neurotransmission. | 2010 |
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19689430 | Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. | 2009 Oct 12 |
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18477562 | Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP. | 2008 Jul 11 |
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18635550 | Functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains. | 2008 Sep 12 |
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17263185 | Phosphodiesterase 10A inhibitors: a novel approach to the treatment of the symptoms of schizophrenia. | 2007 Jan |
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17389385 | Structural insight into substrate specificity of phosphodiesterase 10. | 2007 Apr 3 |
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15627479 | Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. | 2005 Jan 15 |
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10998054 | The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains. | 2000 Oct |
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10373451 | Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). | 1999 Jun 25 |
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10441464 | Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP. | 1999 Aug 11 |
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