Title : β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG.

Pub. Date : 2016 Feb 2

PMID : 26713600






4 Functional Relationships(s)
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Protein Name
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1 Phosphodiesterase 10A (PDE10) is a cGMP and cAMP degrading PDE isozyme that is highly expressed in the brain striatum where it appears to play an important role in cognition and psychomotor activity. Cyclic AMP phosphodiesterase 10A Homo sapiens
2 Phosphodiesterase 10A (PDE10) is a cGMP and cAMP degrading PDE isozyme that is highly expressed in the brain striatum where it appears to play an important role in cognition and psychomotor activity. Cyclic AMP phosphodiesterase 10A Homo sapiens
3 Phosphodiesterase 10A (PDE10) is a cGMP and cAMP degrading PDE isozyme that is highly expressed in the brain striatum where it appears to play an important role in cognition and psychomotor activity. Cyclic AMP phosphodiesterase 10A Homo sapiens
4 Here we report that the concentration range by which the highly specific PDE10 inhibitor, Pf-2545920 (MP-10), inhibits colon tumor cell growth parallels the concentration range required to increase cGMP and cAMP levels, and activates PKG and PKA, respectively. Cyclic AMP phosphodiesterase 10A Homo sapiens