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35563185 | Intramolecular Interaction with the E6 Region Stabilizes the Closed Conformation of the N-SH2 Domain and Concurs with the Self-Inhibitory Docking in Downregulating the Activity of the SHP2 Tyrosine Phosphatase: A Molecular Dynamics Study. | 2022 Apr 27 |
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| 2 |
33755016 | Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. | 2021 Mar 23 |
2 |
| 3 |
34025932 | Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network. | 2021 |
3 |
| 4 |
34734802 | Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors. | 2021 Nov 4 |
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| 5 |
32024694 | A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2). | 2020 Mar 13 |
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| 6 |
32395997 | Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase. | 2020 Jun 22 |
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| 7 |
33043190 | Novel Small-Molecule Inhibitor for the Oncogenic Tyrosine Phosphatase SHP2 with Anti-Breast Cancer Cell Effects. | 2020 Oct 6 |
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| 8 |
30308182 | Stem cell factor and NSC87877 synergism enhances c-Kit mediated proliferation of human erythroid cells. | 2018 Dec 1 |
2 |
| 9 |
28912526 | MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells. | 2017 Sep 14 |
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| 10 |
26191366 | Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. | 2015 Jul 9 |
2 |
| 11 |
26359300 | EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1. | 2015 Nov 1 |
2 |
| 12 |
24632723 | SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. | 2014 |
1 |
| 13 |
23792876 | Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2. | 2013 |
1 |
| 14 |
22589543 | LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane. | 2012 Jun 29 |
1 |
| 15 |
21193311 | Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs. | 2011 Jan 15 |
1 |
| 16 |
19661287 | Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis. | 2009 Dec |
1 |
| 17 |
19948503 | Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. | 2009 Nov 16 |
1 |
| 18 |
15574420 | A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. | 2005 Feb 18 |
1 |
| 19 |
15940693 | PTPN11 mutations play a minor role in isolated congenital heart disease. | 2005 Jul 15 |
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| 20 |
15985432 | Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2. | 2005 Aug 19 |
1 |
| 21 |
16129412 | Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. | 2005 Nov 11 |
1 |
| 22 |
14701753 | Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells. | 2004 Jan |
2 |
| 23 |
15031289 | Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. | 2004 May 28 |
1 |
| 24 |
15289498 | Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. | 2004 Aug 2 |
2 |
| 25 |
12482860 | Crystal structure of human protein-tyrosine phosphatase SHP-1. | 2003 Feb 21 |
1 |
| 26 |
12535670 | Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif. | 2003 Jan 31 |
2 |
| 27 |
12731888 | Chemical dissection of the effects of tyrosine phosphorylation of SHP-2. | 2003 May 13 |
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| 28 |
14508511 | Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase. | 2003 Sep 25 |
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| 29 |
14652006 | Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. | 2003 Dec 26 |
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| 30 |
11323411 | Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. | 2001 Jun 29 |
2 |
| 31 |
11341829 | Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. | 2001 May 15 |
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| 32 |
11342028 | A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin receptor. | 2001 Feb 9 |
3 |
| 33 |
11684012 | Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. | 2001 Oct |
2 |
| 34 |
11737239 | Surfing the insulin signaling web. | 2001 Nov |
1 |
| 35 |
10623804 | Effects of Src homology domain 2 (SH2)-containing inositol phosphatase (SHIP), SH2-containing phosphotyrosine phosphatase (SHP)-1, and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions. | 2000 Jan 15 |
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| 36 |
10742110 | The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. | 2000 Apr |
2 |
| 37 |
10829066 | Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. | 2000 Jun 6 |
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| 38 |
10946280 | Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation. | 2000 Sep 1 |
2 |
| 39 |
10206955 | The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. | 1999 Apr 23 |
2 |
| 40 |
10407071 | Amphiphilic and hydrophilic nature of sheep and human platelet phosphotyrosine phosphatase forms. | 1999 Jul 15 |
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| 41 |
10521483 | Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. | 1999 Oct 22 |
1 |
| 42 |
9254654 | Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival. | 1997 Aug 18 |
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| 43 |
9312087 | Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2. | 1997 Oct 3 |
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| 44 |
8810330 | Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. | 1996 Oct 11 |
2 |
| 45 |
7513703 | Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. | 1994 May 6 |
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| 46 |
7935386 | Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. | 1994 Oct |
1 |
| 47 |
8144631 | SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. | 1994 Apr 8 |
2 |
| 48 |
7681589 | A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. | 1993 Mar 15 |
1 |
| 49 |
7691811 | Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. | 1993 Oct 15 |
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