Title : The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

Pub. Date : 2000 Apr

PMID : 10742110






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity. Phosphotyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens
2 Thus, Shp2 regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis. Phosphotyrosine protein tyrosine phosphatase non-receptor type 11 Homo sapiens