2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ; Homo sapiens







205 Article(s)
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1 34994954 Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K. 2022 Feb 1
2 35222803 Protection of Human Lens Epithelial Cells from Oxidative Stress Damage and Cell Apoptosis by KGF-2 through the Akt/Nrf2/HO-1 Pathway. 2022 1
3 33959949 Concentration-dependent duality of bFGF in regulation of barrier properties of human brain endothelial cells. 2021 Nov 1
4 34399087 Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells. 2021 Oct 1
5 34408780 Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma. 2021 1
6 34603025 Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism. 2021 1
7 34822557 Bee Venom Prevents Mucin 5AC Production through Inhibition of AKT and SPDEF Activation in Airway Epithelia Cells. 2021 Nov 1 1
8 32407984 Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway. 2020 Jul 1
9 32431202 NLRC5 promotes cell migration and invasion by activating the PI3K/AKT signaling pathway in endometrial cancer. 2020 May 1
10 30483746 Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways. 2019 Jan 1
11 30628639 Long non‑coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway. 2019 Mar 1
12 30689624 Sulforaphane Attenuates H₂O₂-induced Oxidant Stress in Human Trabecular Meshwork Cells (HTMCs) via the Phosphatidylinositol 3-Kinase (PI3K)/Serine/Threonine Kinase (Akt)-Mediated Factor-E2-Related Factor 2 (Nrf2) Signaling Activation. 2019 Jan 28 1
13 30796965 Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells. 2019 May 1
14 30942438 Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide‑3 kinase/protein kinase B signaling pathway. 2019 May 1
15 30968158 FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. 2019 Apr 1
16 31142701 Qiliqiangxin Attenuates Oxidative Stress-Induced Mitochondrion-Dependent Apoptosis in Cardiomyocytes via PI3K/AKT/GSK3β Signaling Pathway. 2019 Aug 1 1
17 31759362 The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25. 2019 Nov 1 1
18 29115508 DJ‑1 alleviates high glucose‑induced endothelial cells injury via PI3K/Akt‑eNOS signaling pathway. 2018 Jan 1
19 29137974 Effects and mechanisms of matrix metalloproteinase2 on neural differentiation of induced pluripotent stem cells. 2018 Jan 1 1
20 29330129 Estradiol up-regulates L-type Ca2+ channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway. 2018 May 1
21 29375710 S100A11 promotes human pancreatic cancer PANC-1 cell proliferation and is involved in the PI3K/AKT signaling pathway. 2018 Jan 1
22 29463070 Cigarette Smoke Extract Enhances IL-17A-Induced IL-8 Production via Up-Regulation of IL-17R in Human Bronchial Epithelial Cells. 2018 Apr 30 1
23 29552203 S100A6 promotes the proliferation and migration of cervical cancer cells via the PI3K/Akt signaling pathway. 2018 Apr 1
24 29901139 Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. 2018 Aug 1
25 29932233 IL-1β promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells MGC803 and the cell's stem-like properties through PI3K pathway. 2018 Nov 1
26 29964051 Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway. 2018 Sep 15 1
27 30021868 Distinct Roles of Small GTPases Rac1 and Rac2 in Histamine H4 Receptor-Mediated Chemotaxis of Mast Cells. 2018 Oct 1
28 30622672 Palmitate Stimulates the Epithelial Sodium Channel by Elevating Intracellular Calcium, Reactive Oxygen Species, and Phosphoinositide 3-Kinase Activity. 2018 1
29 27090441 The protective effects of insulin-like growth factor-1 on neurochemical phenotypes of dorsal root ganglion neurons with BDE-209-induced neurotoxicity in vitro. 2017 Mar 1
30 27814668 Orexin-A Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity: Involvement of PKC and PI3K Signaling Pathways. 2017 Apr 1
31 28274303 [Recombinant HBcAg promotes secretion of IL-15 in myeloid dendritic cells via p38MAPK signaling pathway]. 2017 Mar 1
32 28355296 Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells. 2017 1
33 28433890 IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway. 2017 Jul 1
34 28693237 Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction. 2017 Jul 1
35 28833753 Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts. 2017 Dec 1
36 25956684 Advanced glycation end-products and insulin signaling in granulosa cells. 2016 Jul 1
37 26371948 mTOR Complexes Repress Hypertrophic Agonist-Stimulated Expression of Connective Tissue Growth Factor in Adult Cardiac Muscle Cells. 2016 Feb 1
38 26482612 MicroRNA-221 targets PTEN to reduce the sensitivity of cervical cancer cells to gefitinib through the PI3K/Akt signaling pathway. 2016 Mar 1
39 26677144 Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway. 2016 Mar 1
40 27357907 Vitamin E succinate induces apoptosis via the PI3K/AKT signaling pathways in EC109 esophageal cancer cells. 2016 Aug 1
41 27592408 Apelin-13 protects neurovascular unit against ischemic injuries through the effects of vascular endothelial growth factor. 2016 Dec 1
42 27781258 [Research status quo and progression in targeted therapy for advanced gastric cancer]. 2016 Oct 25 1
43 25351625 LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3‑kinase/Akt/fatty acid synthase signaling pathway in vitro. 2015 Feb 1
44 25373458 Heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by high glucose through the phosphoinositide 3‑kinase/Akt and extracellular signal‑regulated kinase 1/2 pathways. 2015 Feb 1
45 25650742 Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. 2015 Jun 1
46 25776934 Caveolin-1 aggravates cigarette smoke extract-induced MUC5AC secretion in human airway epithelial cells. 2015 May 1
47 25869596 Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801. 2015 Oct 1
48 26061016 Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells. 2015 Jun 8 1
49 26062301 The synergistic killing of AML cells co-cultured with HS-5 bone marrow stromal cells by As2O3 and the PI3K/Akt signaling pathway inhibitor LY294002. 2015 May 1
50 24708926 CNTF regulates neurite outgrowth and neuronal migration through JAK2/STAT3 and PI3K/Akt signaling pathways of DRG explants with gp120-induced neurotoxicity in vitro. 2014 May 21 1