Title : IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway.

Pub. Date : 2017 Jul

PMID : 28433890






1 Functional Relationships(s)
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1 Moreover, treatment with an AKT agonist, insulin-like growth factor 1 (IGF-1), reversed these IL-37-mediated effects on autophagy, and treatment with an phosphoinositide-3-kinase (PI3K)/AKT inhibitor, LY294002, mimicked the effects of IL-37. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens