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hypoxia inducible factor 1 subunit alpha ; Homo sapiens







73 Article(s)
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1 34742454 O-carboxymethyl chitosan based pH/hypoxia-responsive micelles relieve hypoxia and induce ROS in tumor microenvironment. 2022 Jan 1 1
2 34936717 TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma. 2022 Apr 1
3 35277473 ACE2-independent infection of T lymphocytes by SARS-CoV-2. 2022 Mar 11 1
4 35380485 HIF-1α protects osteoblasts from ROS-induced apoptosis. 2022 Feb 2
5 32898935 Coenzyme Q biosynthesis inhibition induces HIF-1α stabilization and metabolic switch toward glycolysis. 2021 Mar 1
6 33151579 In vitro temporal HIF-mediated deposition of osteochondrogenic matrix governed by hypoxia and osteogenic factors synergy. 2021 May 1
7 33242123 Retraction Note to: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway. 2021 Mar 1
8 33242463 HIF1α promotes tumor chemoresistance via recruiting GDF15-producing TAMs in colorectal cancer. 2021 Jan 15 1
9 33345265 A paradox: Fe2+-containing agents decreased ROS and apoptosis induced by CoNPs in vascular endothelial cells by inhibiting HIF-1α. 2021 Jan 29 1
10 33388412 Cardiac-specific overexpression of HIF-1α during acute myocardial infarction ameliorates cardiomyocyte apoptosis via differential regulation of hypoxia-inducible pro-apoptotic and anti-oxidative genes. 2021 Jan 22 2
11 33990669 Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells. 2021 May 14 2
12 34141616 Radiation Resistance: A Matter of Transcription Factors. 2021 1
13 35186974 HIF-1α Alleviates High-Glucose-Induced Renal Tubular Cell Injury by Promoting Parkin/PINK1-Mediated Mitophagy. 2021 1
14 32433492 Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. 2020 May 20 1
15 32473132 Severity and duration of hypoxic stress differentially regulates HIF-1α-mediated cardiomyocyte apoptotic signaling milieu during myocardial infarction. 2020 Sep 15 2
16 32503939 Perinuclear mitochondrial clustering, increased ROS levels, and HIF1 are required for the activation of HSF1 by heat stress. 2020 Jul 9 2
17 32640500 Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. 2020 Dec 1
18 32670550 β-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1α/TGF-β/MMPs in A549 cells. 2020 Jun 1
19 32697943 Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis. 2020 Sep 1 2
20 33054172 HIF-1α-Mediated Mitophagy Determines ZnO Nanoparticle-Induced Human Osteosarcoma Cell Death both In Vitro and In Vivo. 2020 Oct 28 1
21 33097055 Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells. 2020 Oct 23 1
22 33246501 Reversibility of hAT-MSCs phenotypic and metabolic changes after exposure to and withdrawal from HCC-conditioned medium through regulation of the ROS/MAPK/HIF-1α signaling pathway. 2020 Nov 27 1
23 33330441 NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production. 2020 1
24 33376580 The Degree of Helicobacter pylori Infection Affects the State of Macrophage Polarization through Crosstalk between ROS and HIF-1α. 2020 2
25 30448556 Overexpression of HIF-1a could partially protect K562 cells from 1,4-benzoquinone induced toxicity by inhibiting ROS, apoptosis and enhancing glycolysis. 2019 Mar 3
26 30696468 Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis. 2019 Jan 29 1
27 30718954 A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells. 2019 1
28 30920152 Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose. 2019 May 1
29 31169018 The combination therapy of HIF1α inhibitor LW6 and cisplatin plays an effective role on anti-tumor function in A549 cells. 2019 Sep 1
30 31176117 Effects of structural distinction in neodymium nanoparticle for therapeutic application in aberrant angiogenesis. 2019 Sep 1 1
31 31481238 Ammonia mediates mitochondrial uncoupling and promotes glycolysis via HIF-1 activation in human breast cancer MDA-MB-231 cells. 2019 Oct 29 1
32 28942242 Hypoxia inducible factor as a therapeutic target for atherosclerosis. 2018 Mar 1
33 29306019 SIRT1 and HIF1α signaling in metabolism and immune responses. 2018 Apr 1 1
34 29435131 PD-L1 confers resistance to EGFR mutation-independent tyrosine kinase inhibitors in non-small cell lung cancer via upregulation of YAP1 expression. 2018 Jan 12 2
35 29702094 ROS mediated EGFR/MEK/ERK/HIF-1α Loop Regulates Glucose metabolism in pancreatic cancer. 2018 Jun 12 9
36 30210529 Impact of FMR1 Premutation on Neurobehavior and Bioenergetics in Young Monozygotic Twins. 2018 1
37 30346453 Ultrasound-targeted photodynamic and gene dual therapy for effectively inhibiting triple negative breast cancer by cationic porphyrin lipid microbubbles loaded with HIF1α-siRNA. 2018 Nov 1 2
38 28065785 A positive feedback loop between ROS and Mxi1-0 promotes hypoxia-induced VEGF expression in human hepatocellular carcinoma cells. 2017 Feb 3
39 28426124 Propofol suppresses LPS-induced nuclear accumulation of HIF-1α and tumor aggressiveness in non-small cell lung cancer. 2017 May 1
40 28435452 The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer. 2017 2
41 28460338 Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome. 2017 Jul 5
42 28926928 Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress. 2017 Nov 1
43 29256392 Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia. 2017 Dec 19 1
44 26480821 Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target. 2016 1
45 26725009 TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. 2016 Jan 21 1
46 26819450 NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma. 2016 Jun 15 1
47 26899267 Melatonin and the von Hippel-Lindau/HIF-1 oxygen sensing mechanism: A review. 2016 Apr 1
48 27058876 Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration. 2016 Jun 1
49 27286880 Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2. 2016 Oct 1
50 27899819 4-cholesten-3-one suppresses lung adenocarcinoma metastasis by regulating translocation of HMGB1, HIF1α and Caveolin-1. 2016 Sep 22 1