Title : Ammonia mediates mitochondrial uncoupling and promotes glycolysis via HIF-1 activation in human breast cancer MDA-MB-231 cells.

Pub. Date : 2019 Oct 29

PMID : 31481238






1 Functional Relationships(s)
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1 Activation of the HIF-1 pathway induced by NH4Cl was inhibited by addition of the antioxidant NAC or the NADPH oxidase (NOX) inhibitor apocynin, indicating the involvement of the NOX-induced ROS generation. ros hypoxia inducible factor 1 subunit alpha Homo sapiens