Title : Cardiac-specific overexpression of HIF-1α during acute myocardial infarction ameliorates cardiomyocyte apoptosis via differential regulation of hypoxia-inducible pro-apoptotic and anti-oxidative genes.

Pub. Date : 2021 Jan 22

PMID : 33388412






2 Functional Relationships(s)
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1 Chromatin immunoprecipitation experiment revealed that HIF-1alpha overexpression in hypoxic cardiomyocytes increases binding of HIF-1alpha to the hypoxia-responsive element in the promoter of its target anti-oxidant gene ho-1 which is known to attenuate ROS accumulation. ros hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Chromatin immunoprecipitation experiment revealed that HIF-1alpha overexpression in hypoxic cardiomyocytes increases binding of HIF-1alpha to the hypoxia-responsive element in the promoter of its target anti-oxidant gene ho-1 which is known to attenuate ROS accumulation. ros hypoxia inducible factor 1 subunit alpha Homo sapiens