Fluorouracil

prostaglandin-endoperoxide synthase 2 ; Homo sapiens







25 Article(s)
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1 32755957 Chitosan nanoparticles loaded with aspirin and 5-fluororacil enable synergistic antitumour activity through the modulation of NF-κB/COX-2 signalling pathway. 2020 Aug 1
2 31341363 Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil resistance in cholangiocarcinoma cells. 2019 Jul 14 1
3 31938347 CD44high/ESAlow squamous cell carcinoma cell-derived prostaglandin E2 confers resistance to 5-fluorouracil-induced apoptosis in CD44high/ESAhigh cells. 2018 2
4 28435473 Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1. 2017 2
5 26844701 Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach. 2016 Feb 4 2
6 25553117 Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway. 2015 2
7 23852449 Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. 2014 Feb 1 4
8 24591842 Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids. 2014 1
9 23347845 Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer. 2013 Jan 24 2
10 23393346 COX-2 overexpression Induced by gene transfer reduces sensitivity of TE13 esophageal carcinoma cells to 5-fluorouracil and cisplatin. 2013 Feb 4
11 22221825 Green tea polyphenol epigallocatechin-3-gallate enhances 5-fluorouracil-induced cell growth inhibition of hepatocellular carcinoma cells. 2012 May 2
12 21868535 Etodolac improves 5-FU sensitivity of head and neck cancer cells through inhibition of thymidylate synthase. 2011 Sep 1
13 22066110 Up-regulation of cyclooxygenase-2-derived prostaglandin E(2) in colon cancer cells resistant to 5-fluorouracil. 2011 Aug 1
14 19830428 Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase. 2010 Jul 2
15 21163769 [Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems]. 2010 Dec 6
16 19048402 Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. 2009 Sep 6
17 19661321 Co-inhibition of cyclooxygenase-2 and dihydropyrimidine dehydrogenase by non-steroidal anti-inflammatory drugs in tumor cells and xenografts. 2009 Aug 4
18 18071320 Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells. 2008 May 8 1
19 16793607 [Diclofenac suppresses hepatoma cell proliferation and promotes cyclooxygenase-2 mRNA expression]. 2006 Jun 1
20 15846114 Rapid up-regulation of cyclooxygenase-2 by 5-fluorouracil in human solid tumors. 2005 Jun 1
21 15896711 Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. 2005 Jul 1 5
22 15014363 Sequence-dependent effect of a cyclooxygenase-2 inhibitor on topoisomerase I inhibitor and 5-fluorouracil-induced cytotoxicity of colon cancer cells. 2004 Mar 1
23 15144595 [Effects of selective cyclooxygenase-2 inhibitor NS-398 on 5-fluorouracil chemotherapy and progression of colon cells: an experimental study]. 2004 Apr 2 5
24 12414664 Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. 2002 Nov 1 1
25 12442003 Synergistic cytotoxicity and apoptosis of JTE-522, a selective cyclooxygenase-2 inhibitor, and 5-fluorouracil against bladder cancer. 2002 Dec 1