Title : Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer.

Pub. Date : 2014 Feb 1

PMID : 23852449






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, treatment of indomethacin alone or combination of 5-FU and indomethacin decreased the expressions of PROM1 (CD133), CD44, PTGS2 (cyclooxygenase 2) and HES1, and increased PPARG expression. Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In addition, treatment of indomethacin alone or combination of 5-FU and indomethacin decreased the expressions of PROM1 (CD133), CD44, PTGS2 (cyclooxygenase 2) and HES1, and increased PPARG expression. Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens
3 NSAIDs could selectively reduce the colon CSCs and suppress 5-FU-induced increase of CSCs via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1, and activating PPARG. Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens
4 NSAIDs could selectively reduce the colon CSCs and suppress 5-FU-induced increase of CSCs via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1, and activating PPARG. Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens