Title : Co-inhibition of cyclooxygenase-2 and dihydropyrimidine dehydrogenase by non-steroidal anti-inflammatory drugs in tumor cells and xenografts.

Pub. Date : 2009 Aug

PMID : 19661321






4 Functional Relationships(s)
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1 It was demonstrated that elevated dihydropyrimidine dehydrogenase (DPD) and COX-2 activities influence the response to 5-fluorouracil (5-FU). Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens
2 It was demonstrated that elevated dihydropyrimidine dehydrogenase (DPD) and COX-2 activities influence the response to 5-fluorouracil (5-FU). Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens
3 We previously showed that NSAIDs increased 5-FU sensitivity only in high COX-2-expressing cancer cells. Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens
4 CONCLUSION: NSAIDs could be promising modulators of fluorouracil-based chemotherapy, especially in high COX-2-expressing tumours. Fluorouracil prostaglandin-endoperoxide synthase 2 Homo sapiens