PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25326806-8 2015 Western blot analysis and immunohistochemical staining revealed that treatment with AZD6244 or BEZ235 could significantly reduce the phosphorylation level of ERK1/2 or AKT in HCT116 tumor tissues. AZD 6244 84-91 mitogen-activated protein kinase 3 Mus musculus 158-164 25541062-0 2015 AZD6244 inhibits cisplatin-induced ERK1/2 activation and potentiates cisplatin-associated cytotoxicity in K-ras G12D preclinical models. AZD 6244 0-7 mitogen-activated protein kinase 3 Mus musculus 35-41 22068161-7 2012 Systemic treatment with selumetinib inhibited cardiac ERK1/2 phosphorylation and blocked increased expression of RNAs encoding natriuretic peptide precursors and proteins involved in sarcomere architecture that occurred in placebo-treated mice. AZD 6244 24-35 mitogen-activated protein kinase 3 Mus musculus 54-60 23815988-7 2013 LmnaH222P/H222P mice were treated with selumetinib, which blocks mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 that activates ERK1/2, from 16 to 20 weeks of age to assess the effects of treatment on muscle histology, ERK1/2 activity and limb grip strength. AZD 6244 39-50 mitogen-activated protein kinase 3 Mus musculus 162-168 17876044-4 2007 AZD6244-inhibited tumor growth was associated with increased apoptosis, inactivation of ERK1/2, inhibition of cell proliferation, and down-regulation of cell cycle regulators, including cyclin D1, cdc-2, cyclin-dependent kinases 2 and 4, cyclin B1, and c-Myc. AZD 6244 0-7 mitogen-activated protein kinase 3 Mus musculus 88-94 17237274-4 2007 Treatment of primary HCC cells with AZD6244 led to growth inhibition, elevation of the cleavage of caspase-3 and caspase-7, and cleaved poly(ADP)ribose polymerase, but inhibition of ERK1/2 and p90RSK phosphorylation. AZD 6244 36-43 mitogen-activated protein kinase 3 Mus musculus 182-188 17237274-8 2007 AZD6244-induced growth suppression was associated with inactivation of ERK1/2 and p90RSK, and up-regulation of activated caspase-3 and caspase-7, and cleaved poly(ADP)ribose polymerase. AZD 6244 0-7 mitogen-activated protein kinase 3 Mus musculus 71-77