PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25326806-8	2015	Western blot analysis and immunohistochemical staining revealed that treatment with AZD6244 or BEZ235 could significantly reduce the phosphorylation level of ERK1/2 or AKT in HCT116 tumor tissues.	AZD 6244	84-91	mitogen-activated protein kinase 3	Mus musculus	158-164	
25541062-0	2015	AZD6244 inhibits cisplatin-induced ERK1/2 activation and potentiates cisplatin-associated cytotoxicity in K-ras G12D preclinical models.	AZD 6244	0-7	mitogen-activated protein kinase 3	Mus musculus	35-41	
22068161-7	2012	Systemic treatment with selumetinib inhibited cardiac ERK1/2 phosphorylation and blocked increased expression of RNAs encoding natriuretic peptide precursors and proteins involved in sarcomere architecture that occurred in placebo-treated mice.	AZD 6244	24-35	mitogen-activated protein kinase 3	Mus musculus	54-60	
23815988-7	2013	LmnaH222P/H222P mice were treated with selumetinib, which blocks mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 that activates ERK1/2, from 16 to 20 weeks of age to assess the effects of treatment on muscle histology, ERK1/2 activity and limb grip strength.	AZD 6244	39-50	mitogen-activated protein kinase 3	Mus musculus	162-168	
17876044-4	2007	AZD6244-inhibited tumor growth was associated with increased apoptosis, inactivation of ERK1/2, inhibition of cell proliferation, and down-regulation of cell cycle regulators, including cyclin D1, cdc-2, cyclin-dependent kinases 2 and 4, cyclin B1, and c-Myc.	AZD 6244	0-7	mitogen-activated protein kinase 3	Mus musculus	88-94	
17237274-4	2007	Treatment of primary HCC cells with AZD6244 led to growth inhibition, elevation of the cleavage of caspase-3 and caspase-7, and cleaved poly(ADP)ribose polymerase, but inhibition of ERK1/2 and p90RSK phosphorylation.	AZD 6244	36-43	mitogen-activated protein kinase 3	Mus musculus	182-188	
17237274-8	2007	AZD6244-induced growth suppression was associated with inactivation of ERK1/2 and p90RSK, and up-regulation of activated caspase-3 and caspase-7, and cleaved poly(ADP)ribose polymerase.	AZD 6244	0-7	mitogen-activated protein kinase 3	Mus musculus	71-77