Title : Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.

Pub. Date : 2012 Feb 1

PMID : 22068161






1 Functional Relationships(s)
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1 Systemic treatment with selumetinib inhibited cardiac ERK1/2 phosphorylation and blocked increased expression of RNAs encoding natriuretic peptide precursors and proteins involved in sarcomere architecture that occurred in placebo-treated mice. AZD 6244 mitogen-activated protein kinase 3 Mus musculus