2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

caspase 3 ; Homo sapiens







78 Article(s)
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1 34558536 Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury. 2022 May 1
2 33486250 Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells. 2021 Jan 11 2
3 33846811 Synergistic effects of LY294002 and ABT199 on the cell cycle in K562, HL60 and KG1a cells. 2021 Jun 2
4 34132431 Suppression of phosphoinositide 3-kinase/phosphoinositide-dependent kinase-1/serum and glucocorticoid-induced protein kinase pathway. 2021 Aug 1
5 34697781 Jolkinolide B attenuates laryngeal cancer cell growth and induces apoptosis via PTEN/PI3K/Akt signaling pathway. 2021 Sep 1
6 31992313 The protective effects of PI3K/Akt pathway on human nucleus pulposus mesenchymal stem cells against hypoxia and nutrition deficiency. 2020 Jan 28 1
7 32173422 Akt/survivin pathway inhibition enhances the apoptotic cell death-induced by alpha-santalol in human prostate cancer cells. 2020 Jun 2
8 32495214 The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells. 2020 Jun 3 1
9 32722075 Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells. 2020 Jul 24 1
10 32922037 CPA4 Promotes EMT in Pancreatic Cancer via Stimulating PI3K-AKT-mTOR Signaling. 2020 1
11 30272818 Microvesicles-mediated communication between endothelial cells modulates, endothelial survival, and angiogenic function via transferring of miR-125a-5p. 2019 Mar 1
12 30296564 TCF21 inhibits proliferation and chemoresistance through the AKT pathway in human gastric cancer. 2019 Jan 15 1
13 31418381 [Angelica Polysaccharide Resists Platelets Apoptosis Induced by LY294002]. 2019 Aug 1
14 29687528 Nobiletin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage. 2018 May 1
15 29956736 Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling. 2018 Sep 2
16 29983082 Orexin-A protects SH-SY5Y cells against H2O2-induced oxidative damage via the PI3K/MEK1/2/ERK1/2 signaling pathway. 2018 Jan-Dec 1
17 30061946 CCL2 influences the sensitivity of lung cancer A549 cells to docetaxel. 2018 Jul 1
18 30259565 Sodium butyrate ameliorates lipopolysaccharide-induced cow mammary epithelial cells from oxidative stress damage and apoptosis. 2018 Sep 26 1
19 30471224 Suppression of Apoptosis in Human Umbilical Vein Endothelial Cells (HUVECs) by Klotho Protein is Associated with Reduced Endoplasmic Reticulum Oxidative Stress and Activation of the PI3K/AKT Pathway. 2018 Nov 24 1
20 27817185 Pharmacologic Inhibition of Autophagy Sensitizes Human Acute Leukemia Jurkat T Cells to Acacetin-Induced Apoptosis. 2017 Jan 28 1
21 28713974 miRNA-125b regulates apoptosis of human non-small cell lung cancer via the PI3K/Akt/GSK3β signaling pathway. 2017 Sep 1
22 28731179 Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway. 2017 Sep 1
23 28775672 Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells. 2017 1
24 26919896 The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells. 2016 May 1 1
25 27018134 Attenuative role of mangiferin in oxidative stress-mediated liver dysfunction in arsenic-intoxicated murines. 2016 Sep 10 1
26 27392709 Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages. 2016 Sep 2 1
27 25638174 Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer. 2015 Feb 1 1
28 26366999 IL-10 Protects Neurites in Oxygen-Glucose-Deprived Cortical Neurons through the PI3K/Akt Pathway. 2015 1
29 24757411 Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway. 2014 1
30 25344912 Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway. 2014 Nov 30 1
31 22457005 TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary Sjögren's syndrome patients. 2013 Feb 1
32 23188122 Extract of Clinopodium chinense inhibits high glucose-induced apoptosis in human umbilical vein endothelial cells. 2013 Apr 1
33 23375756 Tumor necrosis factor-related apoptosis-inducing ligand promotes microvascular endothelial cell hyperpermeability through phosphatidylinositol 3-kinase pathway. 2013 Apr 1
34 23420486 Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells. 2013 1
35 23743572 Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine. 2013 Aug 1
36 23900601 A novel HDAC inhibitor OBP-801 and a PI3K inhibitor LY294002 synergistically induce apoptosis via the suppression of survivin and XIAP in renal cell carcinoma. 2013 Oct 1
37 22994717 LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. 2012 1
38 21245990 LY294002 potentiates the anti-cancer effect of oxaliplatin for gastric cancer via death receptor pathway. 2011 Jan 14 2
39 21300060 Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways. 2011 Apr 15 1
40 21303966 Low-level C-reactive protein levels exert cytoprotective actions on human podocytes. 2011 Aug 1
41 21370247 Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways. 2011 Mar 1
42 20010439 Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis. 2010 Feb 3
43 19278624 Hydrogen peroxide-induced Akt phosphorylation regulates Bax activation. 2009 May 1
44 19513559 Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. 2009 Jul 1
45 19738051 Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. 2009 Sep 15 1
46 19827268 Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. 2009 1
47 18256309 Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. 2008 Apr 1
48 18269934 IGF-I protects human oral buccal mucosal epithelial cells from sodium nitroprusside-induced apoptosis via PI3-kinase. 2008 Aug 1
49 18791828 Rapid and significant induction of TRAIL-mediated type II cells in apoptosis of primary salivary epithelial cells in primary Sjögren's syndrome. 2008 Nov 1
50 17303382 Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2. 2007 Jun 1