Pub. Date : 2011 Jan 14
PMID : 21245990
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LY294002 promoted oxaliplatin-induced Fas ligand (FasL) expression, Fas-associated death domain protein recruitment, caspase-8, Bid, and caspase-3 activation, and the short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP(S)) inhibition. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | caspase 3 | Homo sapiens |
| 2 | In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | caspase 3 | Homo sapiens |