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35388168 | What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy? | 2022 Jun |
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35409052 | Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family. | 2022 Mar 28 |
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34233959 | Pharmacologic Targeting of Mcl-1 Induces Mitochondrial Dysfunction and Apoptosis in B-Cell Lymphoma Cells in a TP53- and BAX-Dependent Manner. | 2021 Sep 1 |
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34942200 | Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics. | 2021 Dec 20 |
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30266036 | ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells. | 2019 Nov |
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| 6 |
28960207 | BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells. | 2018 Jan |
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29335437 | Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors. | 2018 Jan 15 |
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| 8 |
27816990 | Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer. | 2017 Apr |
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| 9 |
27560714 | MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL. | 2016 Aug 25 |
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| 10 |
25715028 | BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. | 2015 |
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25880088 | BCL-2 is dispensable for thrombopoiesis and platelet survival. | 2015 Apr 16 |
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| 12 |
26113054 | AT-101 inhibits hedgehog pathway activity and cancer growth. | 2015 Sep |
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24352880 | Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. | 2014 Feb 6 |
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| 14 |
24632563 | Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. | 2014 Mar 17 |
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| 15 |
23341542 | ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia. | 2013 Mar 21 |
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| 16 |
23440244 | RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model. | 2013 Apr 25 |
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| 17 |
23843527 | Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. | 2013 Jul 10 |
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| 18 |
21768359 | Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737. | 2012 Feb 21 |
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21997189 | Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice. | 2012 Apr |
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| 20 |
22374700 | Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival. | 2012 Jun 14 |
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| 21 |
23213401 | ABT-737 synergizes with Bortezomib to kill melanoma cells. | 2012 Feb 15 |
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| 22 |
20503275 | A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1. | 2011 Apr 1 |
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| 23 |
21719460 | Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis. | 2011 Oct |
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| 24 |
20534453 | BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. | 2010 Jun 15 |
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| 25 |
21033669 | Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. | 2010 Nov 25 |
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| 26 |
19839062 | BH3-only protein bid participates in the Bcl-2 network in healthy liver cells. | 2009 Dec |
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| 27 |
18292288 | Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. | 2008 Jun 1 |
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| 28 |
17404107 | Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1. | 2007 Apr 1 |
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| 29 |
17508927 | Small molecule inhibition of the Bcl-X(L)-BH3 protein-protein interaction: proof-of-concept of an in vivo chemopotentiator ABT-737. | 2007 |
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| 30 |
17536015 | Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. | 2007 Sep 15 |
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| 31 |
16714293 | Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences. | 2006 Jul 28 |
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| 32 |
16780816 | Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia. | 2006 Jul 12 |
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| 33 |
16997913 | Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. | 2006 Oct 3 |
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| 34 |
17097561 | The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. | 2006 Nov |
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| 35 |
15861188 | Bak but not Bax is essential for Bcl-xS-induced apoptosis. | 2005 Jul |
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| 36 |
11709185 | Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. | 2001 Nov |
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| 37 |
10737620 | Correlation between structure of Bcl-2 and its inhibitory function of JNK and caspase activity in dopaminergic neuronal apoptosis. | 2000 Apr |
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| 38 |
10807576 | Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. | 2000 May 12 |
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