Title : Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

Pub. Date : 2006 Oct 3

PMID : 16997913






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Resistance to imatinib caused by Bcl-2 overexpression or loss of Bim (plus Bad) could be overcome by cotreatment with the BH3 mimetic ABT-737. BH 3 B cell leukemia/lymphoma 2 Mus musculus