Title : MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Pub. Date : 2016 Aug 25

PMID : 27560714






1 Functional Relationships(s)
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1 By combining inducible knockout mouse models with the BH3-mimetic compound ABT-737, which inhibits BCL-2, BCL-XL and BCL-W, we found that dependency on MCL-1, BCL-XL or BCL-2 expression changes during B-cell development. BH 3 B cell leukemia/lymphoma 2 Mus musculus