| 1 |
35472745 | Combined inhibition of BET bromodomain and mTORC1/2 provides therapeutic advantage for rhabdomyosarcoma by switching cell death mechanism. | 2022 Apr 26 |
1 |
| 2 |
33790341 | Hydrogen peroxide (H2O2) mediated activation of mTORC2 increases intracellular Na+ concentration in the renal medullary thick ascending limb of Henle. | 2021 Mar 31 |
2 |
| 3 |
34073791 | Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response. | 2021 May 24 |
1 |
| 4 |
32642408 | RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma. | 2020 Jun |
1 |
| 5 |
32990653 | Stimulatory effect of insulin on H+-ATPase in the proximal tubule via the Akt/mTORC2 pathway. | 2020 Oct 17 |
1 |
| 6 |
31081172 | Phosphorylated mTORC1 represses autophagic-related mRNA translation in neurons exposed to ischemia-reperfusion injury. | 2019 Sep |
1 |
| 7 |
31732667 | Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells. | 2019 Dec 3 |
1 |
| 8 |
29195143 | Metabolite identification and pharmacokinetic profiling of PP242, an ATP-competitive inhibitor of mTOR using ultra high-performance liquid chromatography and mass spectrometry. | 2018 Jan 1 |
1 |
| 9 |
29344639 | Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study. | 2018 Apr |
2 |
| 10 |
29692710 | PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT. | 2018 |
2 |
| 11 |
29755672 | Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma. | 2018 Apr 17 |
1 |
| 12 |
29849119 | mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy. | 2018 Sep |
1 |
| 13 |
30131696 | The WT1/MVP-Mediated Stabilization on mTOR/AKT Axis Enhances the Effects of Cisplatin in Non-small Cell Lung Cancer by a Reformulated Yu Ping Feng San Herbal Preparation. | 2018 |
1 |
| 14 |
30356017 | HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis. | 2018 Oct 24 |
1 |
| 15 |
28612529 | [The Mechanism of Combination using mTORC1/2 Inhibitor and Imatinib to Suppress Cell Proliferation of Ph +ALL Cell Line]. | 2017 Mar |
1 |
| 16 |
28679058 | Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats. | 2017 Nov |
2 |
| 17 |
26548560 | PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of rapamycin complex 2/AKT1 signaling pathway. | 2016 Jan |
3 |
| 18 |
26719046 | ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. | 2016 Mar |
2 |
| 19 |
26894601 | Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling. | 2016 Aug |
1 |
| 20 |
27196780 | Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer. | 2016 Jul |
1 |
| 21 |
27358039 | Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors. | 2016 Jun 30 |
1 |
| 22 |
25239638 | An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease. | 2015 Jan |
1 |
| 23 |
25265063 | Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway. | 2015 Feb 1 |
1 |
| 24 |
25440763 | The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. | 2015 Jan |
2 |
| 25 |
25535978 | The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia. | 2015 Apr |
1 |
| 26 |
25918246 | mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation. | 2015 Jul |
2 |
| 27 |
26636543 | mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells. | 2015 Dec 29 |
1 |
| 28 |
24270265 | Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension. | 2014 Feb 25 |
1 |
| 29 |
24316308 | Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer. | 2014 Feb |
1 |
| 30 |
23482748 | Comparative effects of PP242 and rapamycin on mTOR signalling and NOTCH signalling in leukemia cells. | 2013 Mar |
1 |
| 31 |
23528835 | Sustained overexpression of Redd1 leads to Akt activation involved in cell survival. | 2013 Aug 19 |
1 |
| 32 |
23838676 | A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin. | 2013 Oct |
2 |
| 33 |
23991179 | Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma. | 2013 |
4 |
| 34 |
22157018 | Amino acids regulate expression of antizyme-1 to modulate ornithine decarboxylase activity. | 2012 Feb 3 |
1 |
| 35 |
22826565 | Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment. | 2012 Sep 27 |
2 |
| 36 |
22843885 | PI3K/mTOR signaling pathways in medulloblastoma. | 2012 Aug |
1 |