Title : Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma.

Pub. Date : 2013

PMID : 23991179






4 Functional Relationships(s)
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1 The second generation of mTOR inhibitors such as PP242 targets mTOR kinase; thus, they are capable of inhibiting both mTORC1 and mTORC2. PP242 CREB regulated transcription coactivator 2 Mus musculus
2 Western blotting showed that the PP242 inhibition of mTORC2-mediated AKT phosphorylation at Ser 473 (AKT(S473)) was transient only in the first few hours of the PP242 treatment. PP242 CREB regulated transcription coactivator 2 Mus musculus
3 Western blotting showed that the PP242 inhibition of mTORC2-mediated AKT phosphorylation at Ser 473 (AKT(S473)) was transient only in the first few hours of the PP242 treatment. PP242 CREB regulated transcription coactivator 2 Mus musculus
4 To test this notion, we showed that the combination of PP242 with erlotinib, an EGFR small molecule inhibitor, blocked both mTORC1 and mTORC2 kinase activity. PP242 CREB regulated transcription coactivator 2 Mus musculus