Title : Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors.

Pub. Date : 2016 Jun 30

PMID : 27358039






1 Functional Relationships(s)
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1 JNK was activated by PP242, and PP242-induced autophagy was blocked by inhibiting JNK pathway with SP600125 or JNK siRNA, suggesting that JNK activation is required for the mTORC1/2 inhibitor-mediated induction of autophagy in NSCLC cells. PP242 CREB regulated transcription coactivator 2 Mus musculus