| 51 |
31510109 | Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment. | 2019 Sep 10 |
2 |
| 52 |
31598395 | A low dose of AZD8055 enhances radiosensitivity of nasopharyngeal carcinoma cells by activating autophagy and apoptosis. | 2019 |
2 |
| 53 |
31707263 | Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia. | 2019 Dec |
1 |
| 54 |
28696243 | Inhibiting 4EBP1 in Glioblastoma. | 2018 Jan 1 |
2 |
| 55 |
29150352 | Dysregulation of mRNA translation and energy metabolism in cancer. | 2018 Jan |
2 |
| 56 |
29369529 | Diabetes and branched-chain amino acids: What is the link? | 2018 May |
1 |
| 57 |
29414044 | Searching for potential mTOR inhibitors: Ligand-based drug design, docking and molecular dynamics studies of rapamycin binding site. | 2018 Mar |
1 |
| 58 |
29571732 | Induction of MEK/ERK activity by AZD8055 confers acquired resistance in neuroblastoma. | 2018 May 15 |
1 |
| 59 |
29636360 | A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer. | 2018 Jul 15 |
1 |
| 60 |
29691292 | Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR. | 2018 Aug 1 |
1 |
| 61 |
29692710 | PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT. | 2018 |
1 |
| 62 |
29695073 | Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors. | 2018 Apr 24 |
1 |
| 63 |
29752834 | H2 O2 induces PP2A demethylation to downregulate mTORC1 signaling in HEK293 cells. | 2018 Sep |
2 |
| 64 |
29845289 | Dual mTOR/PI3K inhibitor NVP‑BEZ235 arrests colorectal cancer cell growth and displays differential inhibition of 4E‑BP1. | 2018 Aug |
2 |
| 65 |
29899840 | CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128. | 2018 May 25 |
4 |
| 66 |
30231482 | ATP-Induced Increase in Intracellular Calcium Levels and Subsequent Activation of mTOR as Regulators of Skeletal Muscle Hypertrophy. | 2018 Sep 18 |
5 |
| 67 |
30346178 | In Silico Discovery of a Small Molecule Suppressing Lung Carcinoma A549 Cells Proliferation and Inducing Autophagy via mTOR Pathway Inhibition. | 2018 Nov 5 |
3 |
| 68 |
30423811 | NVP-BEZ235 Attenuated Cell Proliferation and Migration in the Squamous Cell Carcinoma of Oral Cavities and p70S6K Inhibition Mimics its Effect. | 2018 Nov 10 |
4 |
| 69 |
27769061 | Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents. | 2017 Jan 24 |
1 |
| 70 |
27860549 | New potential inhibitors of mTOR: a computational investigation integrating molecular docking, virtual screening and molecular dynamics simulation. | 2017 Dec |
1 |
| 71 |
27938509 | Sorafenib and 2-Deoxyglucose Synergistically Inhibit Proliferation of Both Sorafenib-Sensitive and -Resistant HCC Cells by Inhibiting ATP Production. | 2017 Feb 10 |
2 |
| 72 |
28223936 | Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function. | 2017 |
1 |
| 73 |
28235701 | Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors. | 2017 Mar 31 |
1 |
| 74 |
28406046 | DEPDC5 as a potential therapeutic target for epilepsy. | 2017 Jun |
2 |
| 75 |
28442344 | miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway. | 2017 Jun 3 |
2 |
| 76 |
28473727 | Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1. | 2017 May 4 |
1 |
| 77 |
28475291 | An Anti-Cancer Drug Candidate OSI-027 and its Analog as Inhibitors of mTOR: Computational Insights Into the Inhibitory Mechanisms. | 2017 Dec |
1 |
| 78 |
28491867 | Metabolic Reprogramming in Glioma. | 2017 |
1 |
| 79 |
28571824 | Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors. | 2017 Jul 15 |
2 |
| 80 |
28699534 | Discovery and Development of ATP-Competitive mTOR Inhibitors Using Computational Approaches. | 2017 Nov 16 |
1 |
| 81 |
28802038 | TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. | 2017 Aug 10 |
2 |
| 82 |
28813526 | mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity. | 2017 |
1 |
| 83 |
29296217 | Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin. | 2017 Dec 8 |
2 |
| 84 |
25867072 | mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. | 2016 Jan 14 |
1 |
| 85 |
26427479 | The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells. | 2016 |
1 |
| 86 |
26497580 | Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells. | 2016 Jan |
1 |
| 87 |
26563881 | Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin. | 2016 |
1 |
| 88 |
26645406 | Malformin A1 promotes cell death through induction of apoptosis, necrosis and autophagy in prostate cancer cells. | 2016 Jan |
1 |
| 89 |
26692480 | Silencing Nrf2 impairs glioma cell proliferation via AMPK-activated mTOR inhibition. | 2016 Jan 15 |
1 |
| 90 |
26719046 | ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. | 2016 Mar |
1 |
| 91 |
26722032 | Torin2 Potentiates Anticancer Effects on Adult T-Cell Leukemia/Lymphoma by Inhibiting Mammalian Target of Rapamycin. | 2016 Jan |
2 |
| 92 |
26805380 | Targeting mTOR for the treatment of B cell malignancies. | 2016 Nov |
1 |
| 93 |
26902888 | Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. | 2016 Feb 23 |
5 |
| 94 |
26978006 | Long-term acquired everolimus resistance in pancreatic neuroendocrine tumours can be overcome with novel PI3K-AKT-mTOR inhibitors. | 2016 Mar 15 |
1 |
| 95 |
27008180 | Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. | 2016 Mar 23 |
2 |
| 96 |
27055253 | Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer. | 2016 |
2 |
| 97 |
27135971 | Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair. | 2016 May |
1 |
| 98 |
27165605 | Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells. | 2016 May 10 |
2 |
| 99 |
27291151 | Autophagy induction contributes to GDC-0349 resistance in head and neck squamous cell carcinoma (HNSCC) cells. | 2016 Aug 19 |
1 |
| 100 |
27335323 | CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells. | 2016 Jun |
1 |