Adenosine Triphosphate

mechanistic target of rapamycin kinase ; Homo sapiens







245 Article(s)
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201 20028854 AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. 2010 Jan 1 2
202 20089401 Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent. 2010 Feb 15 2
203 20166697 Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor. 2010 Mar 25 1
204 20187447 [Adenosine-triphosphate promoting repair of spinal cord injury by activating mammalian target of rapamycin/signal transducers and activators of transcription 3 signal pathway in rats]. 2010 Feb 3
205 20188551 4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). 2010 Apr 1 2
206 20188552 Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). 2010 Apr 1 4
207 20223663 2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: optimization of human microsomal stability. 2010 Apr 15 1
208 20549474 New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs). 2010 2
209 20569080 New inhibitors of the mammalian target of rapamycin signaling pathway for cancer. 2010 Aug 2
210 20597028 Recent advances in the development of selective, ATP-competitive inhibitors of mTOR. 2010 Jul 2
211 20678995 ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats. 2010 Sep 1 1
212 20804212 Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes. 2010 Oct 5 3
213 20812900 Updates of mTOR inhibitors. 2010 Sep 2
214 20884625 Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia. 2010 Nov 15 1
215 21062993 Akt and autophagy cooperate to promote survival of drug-resistant glioma. 2010 Nov 9 1
216 19150980 An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. 2009 Mar 20 2
217 19209957 Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. 2009 Feb 10 1
218 19416948 Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death. 2009 Jun 1
219 19442097 Diabetes, oxidative stress, nitric oxide and mitochondria function. 2009 May 1
220 19507259 Enhanced IFNgamma production in adenosine-treated CHO cells: a mechanistic study. 2009 May-Jun 1
221 19584280 Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. 2009 Aug 1 2
222 19645448 ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. 2009 Aug 27 2
223 19894727 Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. 2009 Dec 24 2
224 19901542 Targeting mTOR globally in cancer: thinking beyond rapamycin. 2009 Dec 2
225 20622997 mTOR Mediated Anti-Cancer Drug Discovery. 2009 Summer 1
226 18247380 Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose. 2008 Aug 2
227 18401543 The metabolism of proline, a stress substrate, modulates carcinogenic pathways. 2008 Nov 1
228 18606717 Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. 2008 Jul 1
229 18701474 S6K1 plays a key role in glial transformation. 2008 Aug 15 2
230 19568796 Rapamycin and mTOR kinase inhibitors. 2008 Nov 1
231 17244528 Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. 2007 Jan 26 1
232 16847060 The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. 2006 Sep 15 2
233 15522879 Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways. 2005 Jan 21 5
234 15797443 Central roles of Mg2+ and MgATP2- in the regulation of protein synthesis and cell proliferation: significance for neoplastic transformation. 2005 1
235 16027121 Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. 2005 Sep 16 1
236 16193082 Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells. 2005 Dec 3
237 14560960 Role of mTOR signalling in the control of translation initiation and elongation by nutrients. 2004 1
238 14560964 mTOR: a mediator of intracellular homeostasis. 2004 2
239 14684182 mTOR integrates amino acid- and energy-sensing pathways. 2004 Jan 9 2
240 14761947 Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. 2004 Apr 16 1
241 15024032 In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160. 2004 Mar 15 1
242 15561916 Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. 2004 Dec 2
243 11930000 FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. 2002 Apr 2 1
244 12387821 Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP depletion. 2002 Oct 25 2
245 11691993 Mammalian TOR: a homeostatic ATP sensor. 2001 Nov 2 3