Tamoxifen

mechanistic target of rapamycin kinase ; Homo sapiens







59 Article(s)
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1 34287884 Retraction. 2022 Mar 1
2 35169858 Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer. 2022 Apr 2
3 35434034 Metformin reverses tamoxifen resistance through the lncRNA GAS5-medicated mTOR pathway in breast cancer. 2022 Mar 1
4 33861751 CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells. 2021 5
5 34619972 Tumor-associated macrophages increase COX-2 expression promoting endocrine resistance in breast cancer via the PI3K/Akt/mTOR pathway. 2021 Sep 1
6 31604073 Knockdown of PTEN decreases expression of estrogen receptor β and tamoxifen sensitivity of human breast cancer cells. 2020 Jan 1
7 31710162 Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer. 2020 Jan 1
8 32521278 Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade. 2020 Jun 9 1
9 32668964 MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway. 2020 1
10 32825760 Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways. 2020 Aug 21 1
11 32921987 Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer. 2020 3
12 30145819 Inhibitory role of large intergenic noncoding RNA-ROR on tamoxifen resistance in the endocrine therapy of breast cancer by regulating the PI3K/Akt/mTOR signaling pathway. 2019 Feb 5
13 30304547 Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway. 2019 Jan 6
14 30542717 Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression. 2019 Jan 3
15 30747221 Downregulation of BAG‑1 in T47D cells promotes resistance to tamoxifen via activation of the PI3K/Akt/mTOR signaling pathway. 2019 Mar 1
16 31088266 Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway. 2019 Jan 1 1
17 31195027 Phospho-mTOR expression in human glioblastoma microglia-macrophage cells. 2019 Oct 1
18 31519767 Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells. 2019 Nov 2
19 31657150 Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer. 2019 Dec 1
20 29345254 The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8. 2018 Aug 1
21 29934412 Endocrine Therapy in Premenopausal Hormone Receptor Positive/Human Epidermal Growth Receptor 2 Negative Metastatic Breast Cancer: Between Guidelines and Literature. 2018 Aug 1
22 30154572 Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells. 2018 Aug 28 2
23 28231748 Aloe-Emodin Enhances Tamoxifen Cytotoxicity by Suppressing Ras/ERK and PI3K/mTOR in Breast Cancer Cells. 2017 3
24 28675785 GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. 2017 Oct 1
25 29269484 Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming. 2017 Nov 15 3
26 27020861 AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment. 2016 Jun 1 1
27 27027343 Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells. 2016 May 3 1
28 27425661 mTOR inhibitors for management of encapsulating peritoneal sclerosis: a review of literatures. 2016 Nov 1
29 27526942 CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway. 2016 Aug 15 3
30 27765938 Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances Tamoxifen Resistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway. 2016 Oct 21 2
31 25361980 Translational studies within the TAMRAD randomized GINECO trial: evidence for mTORC1 activation marker as a predictive factor for everolimus efficacy in advanced breast cancer. 2015 Jan 1
32 25799952 Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism. 2015 Jun 28 3
33 25882671 Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion. 2015 1
34 25972244 S6 kinase signaling: tamoxifen response and prognostic indication in two breast cancer cohorts. 2015 Jun 2
35 26158266 Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells. 2015 1
36 26208432 mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells. 2015 Oct 10 6
37 26436206 Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. 2015 Nov 13 1
38 24519842 m-TOR inhibitors may be useful in the treatment of encapsulating peritoneal sclerosis (EPS). 2014 Oct 2
39 24612549 Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma. 2014 Mar 11 1
40 25108739 Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival. 2014 Sep 1
41 23242584 Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit. 2013 Jan 6
42 23299092 Advances in the treatment of luminal breast cancer. 2013 Feb 1
43 23799775 Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities. 2013 Jul 25 1
44 23814023 Dual inhibition of PI3K and mTOR mitigates compensatory AKT activation and improves tamoxifen response in breast cancer. 2013 Oct 1
45 23844917 Endocrine therapy: is the first generation of targeted drugs the last? 2013 Aug 1
46 23991038 Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling. 2013 1
47 23999849 Biologic impact and clinical implication of mTOR inhibition in metastatic breast cancer. 2013 Sep 27 2
48 24131622 The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. 2013 1
49 22835717 Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure. 2012 Nov 2
50 22922893 Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance in breast cancer cells. 2012 Nov 1