Title : Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities.

Pub. Date : 2013 Jul 25

PMID : 23799775






1 Functional Relationships(s)
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1 The PI3K/Akt/mTOR pathway was attenuated by pretreatment with Cl(-) channel blockers [tamoxifen and 5-nitro-2-(3-phenylpropylamino)benzoic acid, NPPB] or ClC-3 small interfereing RNA. Tamoxifen mechanistic target of rapamycin kinase Homo sapiens