Title : Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways.

Pub. Date : 2020 Aug 21

PMID : 32825760






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1 We have demonstrated metformin"s ability to enhance the cytostatic activity of the tamoxifen and rapamycin on both parent MCF-7 cells and MCF-7-resistant derivates mediated via the suppression of mTOR signaling and growth-related transcriptional factors. Tamoxifen mechanistic target of rapamycin kinase Homo sapiens