Title : TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.

Pub. Date : 2013 Oct

PMID : 23913164






2 Functional Relationships(s)
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1 Critically, knockdown of TDP1 or inhibition of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme in the same complex as TDP1, sensitized rhabdomyosarcoma cell lines to analogues of irinotecan. Irinotecan poly(ADP-ribose) polymerase 1 Homo sapiens
2 Critically, knockdown of TDP1 or inhibition of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme in the same complex as TDP1, sensitized rhabdomyosarcoma cell lines to analogues of irinotecan. Irinotecan poly(ADP-ribose) polymerase 1 Homo sapiens