Doxorubicin

poly(ADP-ribose) polymerase 1 ; Homo sapiens







87 Article(s)
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1 35393219 Synthesis of novel dual target inhibitors of PARP and EGFR and their antitumor activities in triple negative breast cancers. 2022 May 1 1
2 33389242 A novel method to detect intracellular metabolite alterations in MCF-7 cells by doxorubicin induced cell death. 2021 Jan 3 1
3 33813001 Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase. 2021 Jul 1 1
4 34619528 Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. 2021 Nov 2
5 34906277 Evaluation of Poly(ADP-ribose) Polymerase Inhibitor, Pamiparib (BGB-290) in Treating Acute Myeloid Leukemia and the Characterization of Its Nanocarrier. 2021 Nov 1 3
6 31420991 NRF2/ABCB1-mediated efflux and PARP1-mediated dampening of DNA damage contribute to doxorubicin resistance in chronic hypoxic HepG2 cells. 2020 Feb 3
7 31989039 CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells. 2020 Jan 1
8 32055930 Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up. 2020 Apr 1
9 32061787 A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines. 2020 Jun 1
10 32345117 Long non-coding RNA H19 regulates proliferation and doxorubicin resistance in MCF-7 cells by targeting PARP1. 2020 Dec 4
11 32919690 Folic acid-modified bovine serum albumin nanoparticles with doxorubicin and chlorin e6 for effective combinational chemo-photodynamic therapy. 2020 Dec 2
12 30326402 Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity. 2019 Feb 2
13 30431088 PARP inhibitor re‑sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis. 2019 Jan 1
14 30448557 Poly(ADP-ribose) polymerase-1 promotes expression of miR-155 by the up-regulation of methyl-CpG binding domain protein 2 in TK6 cells exposed to hydroquinone. 2019 Mar 2
15 30937974 Costunolide enhances sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin through PI3K/Akt pathway. 2019 Jun 1
16 31215481 MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer. 2019 Jun 18 1
17 31861131 Simultaneous Multi-Organ Metastases from Chemo-Resistant Triple-Negative Breast Cancer Are Prevented by Interfering with WNT-Signaling. 2019 Dec 17 1
18 29254044 pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells. 2018 Feb 1 1
19 29309757 Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK. 2018 Feb 1
20 29784019 The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma. 2018 May 21 2
21 29959912 SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling. 2018 Sep 15 2
22 30166110 Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin. 2018 Aug 1 2
23 28222632 Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity. 2017 Feb 1
24 28498322 Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Cytotoxic Effects in Hepatocellular Carcinoma Cells. 2017 May 12 1
25 28653879 TP53 alteration determines the combinational cytotoxic effect of doxorubicin and an antioxidant NAC. 2017 Jun 1
26 28791810 Cytotoxicity of anticancer drugs and PJ-34 (poly(ADP-ribose)polymerase-1 (PARP-1) inhibitor) on HL-60 and Jurkat cells. 2017 May-Jun 1
27 28827731 MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy. 2017 Aug 21 2
28 29201109 Evaluation of Apoptosis in Multipotent Hematopoietic Cells of Bone Marrow by Anthracycline Antibiotics. 2017 Summer 3
29 26505786 Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways. 2016 Jan 11 2
30 26525975 Synergic Effects of Doxorubicin and Melatonin on Apoptosis and Mitochondrial Oxidative Stress in MCF-7 Breast Cancer Cells: Involvement of TRPV1 Channels. 2016 Apr 1
31 26943039 Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. 2016 Apr 5 3
32 27565811 Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. 2016 Oct 2
33 27898232 Unfolded Protein Response Promotes Doxorubicin-Induced Nonsmall Cell Lung Cancer Cells Apoptosis via the mTOR Pathway Inhibition. 2016 Dec 1
34 25938539 PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression. 2015 Jun 20 3
35 26101222 Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity. 2015 Sep 1
36 26438158 PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway. 2015 Dec 1
37 26522181 Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53. 2015 Nov 2 6
38 26881525 Doxorubicin enhances (131)I-rituximab induced cell death in Raji cells. 2015 Oct-Dec 1
39 24245692 Suppression of NF-κB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer. 2014 1
40 24247637 Combination treatment with paclitaxel and doxorubicin inhibits growth of human esophageal squamous cancer cells by inactivation of Akt. 2014 Jan 1
41 24675890 Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner. 2014 4
42 24811541 Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435/DOX cells. 2014 Aug 4 1
43 24998637 Induction of apoptosis by doxorubicin-transferrin conjugate compared to free doxorubicin in the human leukemia cell lines. 2014 Sep 5 3
44 25066396 Inhibited effects of veliparib combined doxorubicin for BEL-7404 proliferation of human liver cancer cell line. 2014 Jun 1
45 25168906 Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs. 2014 Aug 29 1
46 25337234 Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells. 2014 5
47 25367122 Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells. 2014 Nov 3 1
48 25377255 The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells. 2014 Nov 5
49 23503641 Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro. 2013 May 1
50 23582862 Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer. 2013 Jul 1