Title : CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells.

Pub. Date : 2020 Jan

PMID : 31989039






1 Functional Relationships(s)
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1 With both BRCA1m and PARP1m, the TNBC cells were more sensitive to three representative chemotherapeutic breast cancer drugs, doxorubicin, gemcitabine and docetaxel, compared with the PARP1 wild-type counterpart in the 2D culture environment. Doxorubicin poly(ADP-ribose) polymerase 1 Homo sapiens