Pub. Date : 2014
PMID : 25337234
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells. | Doxorubicin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | To study the effects of adriamycin on the expression of BRCA1 and PARP-1 in BRCA1 wild-type MCF-7 cells. | Doxorubicin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | We used Western blotting to detect BRCA1 and PARP-1 levels in MCF-7 cells treated with adriamycin, and used flow cytometry to detect apoptotic MCF-7 cells. | Doxorubicin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | Results showed that adriamycin can increase PARP-1 activation in a dose- and time-dependent manner. | Doxorubicin | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 5 | All of these suggested that adriamycin can affect the PARP-1 activation and the expression of BRCA1. | Doxorubicin | poly(ADP-ribose) polymerase 1 | Homo sapiens |