Pub. Date : 2021 Sep
PMID : 34117512
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: SN-38, a pharmacologically active metabolite of irinotecan, is taken up into hepatocytes by organic anion transporting polypeptide (OATP) 1B1. | Irinotecan | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | PURPOSE: SN-38, a pharmacologically active metabolite of irinotecan, is taken up into hepatocytes by organic anion transporting polypeptide (OATP) 1B1. | Irinotecan | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | The effects of functional OATP1B1 521T>C on the pharmacokinetics of SN-38 remain controversial. | Irinotecan | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | Here, we prospectively examined the effects of OATP1B1 function on the area under the plasma total or unbound concentration-time curve (tAUC or uAUC) of SN-38 by assessing OATP1B1 521T>C and the plasma levels of endogenous OATP1B1 substrates, coproporphyrin (CP)-I and III, in cancer patients treated with irinotecan. | Irinotecan | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | Here, we prospectively examined the effects of OATP1B1 function on the area under the plasma total or unbound concentration-time curve (tAUC or uAUC) of SN-38 by assessing OATP1B1 521T>C and the plasma levels of endogenous OATP1B1 substrates, coproporphyrin (CP)-I and III, in cancer patients treated with irinotecan. | Irinotecan | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 6 | CONCLUSION: The contribution of OATP1B1 activity to inter-patient variability in the systemic exposure to SN-38 is likely minimal in patients without severe renal failure. | Irinotecan | solute carrier organic anion transporter family member 1B1 | Homo sapiens |