Title : OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.

Pub. Date : 2014 Feb

PMID : 24194565






2 Functional Relationships(s)
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1 Impaired hepatic clearance due to low-activity polymorphisms in human OATP1B1 may increase systemic exposure to SN-38, the active and toxic metabolite of the anticancer prodrug irinotecan. Irinotecan solute carrier organic anion transporter family member 1B1 Homo sapiens
2 Impaired hepatic clearance due to low-activity polymorphisms in human OATP1B1 may increase systemic exposure to SN-38, the active and toxic metabolite of the anticancer prodrug irinotecan. Irinotecan solute carrier organic anion transporter family member 1B1 Homo sapiens