Bortezomib

BCL2 apoptosis regulator ; Homo sapiens







105 Article(s)
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1 33376542 Inhibition of autophagy enhances apoptosis induced by bortezomib in AML cells. 2021 Feb 1
2 34508613 Bortezomib enhances the anti-cancer effect of the novel Bruton's tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK. 2021 Sep 10 1
3 34608124 Severe cellular stress activates apoptosis independently of p53 in osteosarcoma. 2021 Oct 4 2
4 34622346 Cluster Gauss-Newton and CellNOpt Parameter Estimation in a Small Protein Signaling Network of Vorinostat and Bortezomib Pharmacodynamics. 2021 Oct 7 1
5 34837676 AntagomiR-19a Induced Better Responsiveness to Bortezomib in Myeloma Cell Lines. 2021 Oct 1
6 32551032 BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis. 2020 1
7 33191863 Blockade of PLD1 potentiates the antitumor effects of bortezomib in multiple myeloma cells by inhibiting the mTOR/NF-κB signal pathway. 2020 Dec 1
8 30535471 MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2. 2019 Feb 1
9 30929387 [Effects of artesunate combined with bortezomib on apoptosis and autophagy of acute myeloid leukemia cells in vitro and its mechanism]. 2019 Mar 14 1
10 31432126 [Corrigendum] MicroRNA‑497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl‑2. 2019 Oct 1
11 28905994 MicroRNA-324-5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting hedgehog signaling. 2018 Jan 1 1
12 29057477 The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs. 2018 May 1
13 30292410 Enhanced antitumor effect of combination of annexin A1 knockdown and bortezomib treatment in multiple myeloma in vitro and in vivo. 2018 Nov 2 1
14 28000897 Bortezomib induces apoptosis and suppresses cell growth and metastasis by inactivation of Stat3 signaling in chondrosarcoma. 2017 Feb 1
15 28281027 Proteasome inhibitors against amelanotic melanoma. 2017 Dec 1
16 28356941 Aspirin enhances the cytotoxic activity of bortezomib against myeloma cells via suppression of Bcl-2, survivin and phosphorylation of AKT. 2017 Feb 2
17 28487980 Combination of bortezomib and daunorubicin in the induction of apoptosis in T-cell acute lymphoblastic leukemia. 2017 Jul 3
18 28964970 Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation. 2017 Dec 1
19 26657288 Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma. 2016 Jan 19 1
20 26939706 Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models. 2016 May 2
21 27769058 Bortezomib-resistance is associated with increased levels of proteasome subunits and apoptosis-avoidance. 2016 Nov 22 1
22 27822577 Combined bortezomib-based chemotherapy and p53 gene therapy using hollow mesoporous silica nanospheres for p53 mutant non-small cell lung cancer treatment. 2016 Dec 20 1
23 27863383 Adipocytes secreted leptin is a pro-tumor factor for survival of multiple myeloma under chemotherapy. 2016 Dec 27 1
24 25373508 ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in "double hit" lymphoma cells. 2015 Jul 1
25 25528518 The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome. 2015 Feb 5 1
26 25602436 Bortezomib inhibits gastric carcinoma HGC-27 cells through the phospho-Jun N-terminal kinase (p-JNK) pathway in vitro. 2015 Apr 1 1
27 25714012 Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma. 2015 Sep 29 2
28 25973303 Inhibition of autophagy enhances the anticancer activity of bortezomib in B-cell acute lymphoblastic leukemia cells. 2015 1
29 25975837 ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2. 2015 Sep 1
30 25995634 Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanoparticles combined with nontoxic concentration of bortezomib and gambogic acid in RPMI-8226 cells. 2015 1
31 26171069 Synergistic effects of cisplatin and proteasome inhibitor bortezomib on human bladder cancer cells. 2015 Jul 3
32 26378933 Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma. 2015 1
33 26472030 Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. 2015 Nov 10 1
34 26544558 Synergistic Effect and Molecular Mechanism of Homoharringtonine and Bortezomib on SKM-1 Cell Apoptosis. 2015 1
35 23697845 Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma. 2014 Feb 1
36 25120804 Bortezomib-based chemotherapy regimens can improve response in newly diagnosed multiple myeloma patients with bcl-2 and survivin overexpression. 2014 2
37 23449448 Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells. 2013 Feb 28 1
38 24086672 JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells. 2013 1
39 24377552 Effects of arsenic trioxide alone and in combination with bortezomib in multiple myeloma RPMI 8266 cells. 2013 1
40 21993018 Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation. 2012 Jan 1 1
41 22054286 Bortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple myeloma. 2012 Jun 4
42 22145750 Proteasome inhibitor bortezomib overcomes P-gp-mediated multidrug resistance in resistant leukemic cell lines. 2012 Jun 1
43 22559167 Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model. 2012 May 4 1
44 22895144 Phase II clinical trial of first or second-line treatment with bortezomib in patients with malignant pleural mesothelioma. 2012 Sep 1
45 21247388 Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. 2011 Mar 2
46 21340723 Synergistic effect of bortezomib and valproic acid treatment on the proliferation and apoptosis of acute myeloid leukemia and myelodysplastic syndrome cells. 2011 Aug 1
47 21454712 Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells. 2011 May 20 3
48 21459798 Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway. 2011 May 15 1
49 21729550 [Effect of curcumin in combination with bortezomib on proliferation and apoptosis of human multiple myeloma cell line H929 and its mechanism]. 2011 Jun 1
50 22169296 [Mechanism associated to enhancing the sensitivity of myeloma cells U266 to bortezomib by 2-methoxyestradiol]. 2011 Dec 1