Pub. Date : 2011 May 20
PMID : 21454712
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells. | Bortezomib | BCL2 apoptosis regulator | Homo sapiens |
| 2 | When killing by bortezomib (an agent whose cytotoxicity in Jurkat T-cell leukemia cells is dependent on Noxa) was examined, apoptosis was enhanced by the Bcl-2/Bcl-x(L) antagonist ABT-737 or by Bcl-2 down-regulation and diminished by Bcl-2 overexpression. | Bortezomib | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Collectively, these observations not only establish the ability of Noxa and Bcl-2 to interact but also identify Bcl-2 overexpression as a potential mechanism of bortezomib resistance. | Bortezomib | BCL2 apoptosis regulator | Homo sapiens |