Title : Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells.

Pub. Date : 2015 Nov 10

PMID : 26472030






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Bortezomib inhibits the ubiquitin/proteasome pathway to achieve its anti-cancer effect and its well characterized activity is the NF-kappaB inhibition through which the anti-apoptotic bcl-2 expression is down-regulated and apoptosis is subsequently induced. Bortezomib BCL2 apoptosis regulator Homo sapiens