Genistein

BCL2 apoptosis regulator ; Homo sapiens







53 Article(s)
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1 33347704 Genistein enhances the effects of L-asparaginase on inducing cell apoptosis in human leukemia cancer HL-60 cells. 2021 May 1
2 31958764 Clinical characteristics of colorectal cancer patients and anti-neoplasm activity of genistein. 2020 Apr 1
3 33745261 Genistein Induces Bcl-2 Expression in Human Dermal Microvascular Endothelial Cells: a Short Report. 2020 6
4 30450837 Genistein inhibits Aβ25-35 -induced SH-SY5Y cell damage by modulating the expression of apoptosis-related proteins and Ca2+ influx through ionotropic glutamate receptors. 2019 Feb 2
5 30618158 Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo. 2019 Apr 1
6 31360194 Genistein-triggered anticancer activity against liver cancer cell line HepG2 involves ROS generation, mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of cell migration. 2019 Jul 1
7 31438633 Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway. 2019 Aug 21 1
8 31538075 Effects of genistein on anti-tumor activity of cisplatin in human cervical cancer cell lines. 2019 Sep 1
9 30003731 Effect of genistein on apoptosis of lung adenocarcinoma A549 cells and expression of apoptosis factors. 2018 May-Jun 1
10 30106049 Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein. 2018 Aug 1
11 29202800 Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-κB/slug/E-cadherin pathway. 2017 Dec 4 1
12 27121018 Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. 2016 Jun 3
13 25675448 Genistein induces apoptosis by the inactivation of the IGF-1R/p-Akt signaling pathway in MCF-7 human breast cancer cells. 2015 Mar 2
14 26064333 ATRA and Genistein synergistically inhibit the metastatic potential of human lung adenocarcinoma cells. 2015 2
15 26841510 [Cytoprotective Effects of Phytoestrogen Genistein against Cancer Cells]. 2015 Nov-Dec 1
16 24573886 Genistein induces apoptosis and autophagy in human breast MCF-7 cells by modulating the expression of proapoptotic factors and oxidative stress enzymes. 2014 May 1
17 25128065 Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-κB) pathway. 2014 Nov 1
18 22227334 IGF-I receptor signaling pathway is involved in the neuroprotective effect of genistein in the neuroblastoma SK-N-SH cells. 2012 Feb 29 1
19 22493348 Physiological concentrations of genistein and 17β-estradiol inhibit MDA-MB-231 breast cancer cell growth by increasing BAX/BCL-2 and reducing pERK1/2. 2012 Apr 3
20 20824697 Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine-resistant pancreatic cancer cells in vitro and in vivo. 2011 Mar 1 1
21 21078540 Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-κB. 2011 Feb 1 1
22 19800779 Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells. 2010 Sep 2
23 19813266 Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells. 2010 Mar 3
24 19932626 Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells. 2010 Jan 21 2
25 19994890 Anticancer effects of flavonoid derivatives isolated from Millettia reticulata Benth in SK-Hep-1 human hepatocellular carcinoma cells. 2010 Jan 27 1
26 20067268 Genistein suppresses tumor necrosis factor-alpha-induced proliferation via the apoptotic signaling pathway in human aortic smooth muscle cells. 2010 Feb 10 1
27 19082897 Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase. 2009 Jan 1
28 19393315 Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelium injury. 2009 Jul 15 2
29 19732843 Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. 2009 Dec 1
30 18357397 The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. 2008 Apr 1
31 18388472 Sensitization of the apoptotic effect of gamma-irradiation in genistein-pretreated CaSki cervical cancer cells. 2008 Mar 1
32 18470428 [Effects of genistein on the expressions of cell apoptosis-related proteins in salivary adenoid cystic carcinoma cell line SACC-83]. 2008 Apr 2
33 18761399 Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway. 2008 Oct 3
34 17786319 Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanisms. 2007 Oct 4
35 15907805 Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents. 2005 Jul 1 1
36 16329599 [Effects of genistein on proliferation and apoptosis in HT-29 cells]. 2005 Sep 1
37 15135300 Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells. 2004 Jun 1 2
38 15188515 Apoptosis of human primary gastric carcinoma cells induced by genistein. 2004 Jun 15 2
39 15288519 The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress. 2004 Sep 2
40 15488634 Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. 2004 Nov 25 1
41 15659824 Proapoptotic potentials of genistein under growth stimulation by estrogen. 2004 Dec 1
42 12948406 [Proliferation inhibition and apoptosis onset in human ovarian carcinoma cell line SKOV3 induced by Genistein]. 2003 Jun 1
43 12950722 Genistein enhances the cisplatin-induced inhibition of cell growth and apoptosis in human malignant melanoma cells. 2003 Oct 1
44 14707277 Genistein sensitizes diffuse large cell lymphoma to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. 2003 Dec 1
45 12239620 Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells. 2002 Oct 2
46 11316564 Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways. 2001 May 1 1
47 11751518 Genistein elicits pleiotropic molecular effects on head and neck cancer cells. 2001 Dec 1
48 11767000 Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer. 2001 Nov 2
49 11074606 Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. 2000 Oct 1
50 11110847 Bcl-2 is not reduced in the death of MCF-7 cells at low genistein concentration. 2000 Dec 1