Title : Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine-resistant pancreatic cancer cells in vitro and in vivo.

Pub. Date : 2011 Mar 1

PMID : 20824697






1 Functional Relationships(s)
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1 Drug resistance of PC is allegedly linked with both constitutive and OxP-induced activation of NF-kappaB, and we found that inactivation of (nuclear factor kappa B) NF-kappaB by genistein before treatment of cells with OxP was required for cell killing, which was consistent with the downregulation of NF-kappaB and its downstream antiapoptotic genes (Bcl-2, XIAPs and survivin). Genistein BCL2 apoptosis regulator Homo sapiens