Tyrosine

signal transducer and activator of transcription 2 ; Homo sapiens







53 Article(s)
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1 35085949 Porcine circovirus type 2 infection inhibits the activation of type I interferon signaling via capsid protein and host gC1qR. 2022 Mar 1
2 33328346 Interactions of the Nipah Virus P, V, and W Proteins across the STAT Family of Transcription Factors. 2020 Dec 16 1
3 27852626 Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387. 2017 Jan 17 1
4 27802159 Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response. 2016 Nov 15 3
5 23878400 The human RVB complex is required for efficient transcription of type I interferon-stimulated genes. 2013 Oct 1
6 24416652 STAT2 phosphorylation and signaling. 2013 Oct 1 1
7 24470978 STATs get their move on. 2013 Oct 1 1
8 22306001 Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2. 2012 Jul 1 1
9 22490698 [Role of auto-secreted interferon α in all-trans retinoic acid-induced expression of RIG-G gene]. 2012 Jan 10 2
10 21498520 Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2. 2011 Jun 10 1
11 21886773 HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2. 2011 1
12 20038197 STAT-phosphorylation-independent induction of interferon regulatory factor-9 by interferon-beta. 2010 Mar 1
13 20068068 Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2. 2010 Jan 2
14 20428775 Global changes of mRNA expression reveals an increased activity of the interferon-induced signal transducer and activator of transcription (STAT) pathway by repression of miR-221/222 in glioblastoma U251 cells. 2010 Jun 1
15 17442890 A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis. 2007 Jul 3
16 16501077 Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2. 2006 Mar 1
17 16507591 IFN-type-I-mediated signaling is regulated by modulation of STAT2 nuclear export. 2006 Mar 15 1
18 16595158 Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway. 2006 Aug 1
19 15767445 Mumps virus V protein antagonizes interferon without the complete degradation of STAT1. 2005 Apr 1
20 15883169 A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses. 2005 May 16 1
21 16107341 Modification of the Stat1 SH2 domain broadly improves interferon efficacy in proportion to p300/CREB-binding protein coactivator recruitment. 2005 Oct 7 1
22 16324217 Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells. 2005 Dec 2 1
23 14600148 Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells. 2004 Jan 30 1
24 14690454 Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C. 2004 Apr 1 1
25 14722125 Identification of a novel conserved motif in the STAT family that is required for tyrosine phosphorylation. 2004 Mar 26 1
26 15166220 Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. 2004 Jul 30 7
27 15175343 STAT2 nuclear trafficking. 2004 Sep 17 3
28 12610111 The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling. 2003 Mar 2
29 12804771 Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation. 2003 Jun 19 1
30 11786546 Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. 2002 Mar 22 1
31 11802163 IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff. 2002 Feb 1
32 12105218 STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues. 2002 Sep 20 1
33 12220192 Affinity of Stat2 for the subunits of the interferon alpha receptor. 2002 Sep 17 1
34 11369622 Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells. 2001 Jun 1 2
35 11408801 Interferon alpha induction of Stat1 and Stat2 and their prognostic significance in carcinoid tumors. 2001 1
36 9933596 The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon alpha-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3. 1999 Feb 12 5
37 10454351 Activation of the Jak-Stat pathway in cells that exhibit selective sensitivity to the antiviral effects of IFN-beta compared with IFN-alpha. 1999 Jul 1
38 10586107 [Interferon signaling pathways]. 1999 Nov 1
39 9461596 Definition of the interferon-alpha receptor-binding domain on the TYK2 kinase. 1998 Feb 13 1
40 9605150 IFN-gamma priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs. 1998 Jun 1 1
41 9677371 Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor. 1998 Jul 31 2
42 9121453 Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. 1997 Apr 3
43 9218843 Rescue by cytokines of apoptotic cell death induced by IL-2 deprivation of human antigen-specific T cell clones. 1997 Jul 1
44 9242679 Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. 1997 Aug 8 1
45 8524306 Function of Stat2 protein in transcriptional activation by alpha interferon. 1996 Jan 1
46 8626752 Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation. 1996 Feb 23 1
47 8628273 Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction. 1996 May 2
48 8657115 Inhibition of alpha interferon but not gamma interferon signal transduction by phorbol esters is mediated by a tyrosine phosphatase. 1996 Apr 1
49 8918689 The genomic structure and chromosomal localization of the mouse STAT3 gene. 1996 Aug 1
50 7529187 Induction of expression of interferon-stimulated gene factor-3 (ISGF-3) proteins by interferons. 1995 Jan 1