Title : Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor.

Pub. Date : 1998 Jul 31

PMID : 9677371






2 Functional Relationships(s)
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1 The region surrounding phosphorylated tyrosine 466 subsequently acts as a docking site for the SH2 domain of Stat2, facilitating phosphorylation of the latter and, thus, the transduction of the IFNalpha signal. Tyrosine signal transducer and activator of transcription 2 Homo sapiens
2 In this report site-specific mutagenesis was employed to analyze the nature of the interaction between the SH2 domain of Stat2 and the region surrounding tyrosine 466 on IFNaR1. Tyrosine signal transducer and activator of transcription 2 Homo sapiens