| 1 |
34648192 | Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine. | 2022 Feb |
1 |
| 2 |
34110134 | Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations. | 2021 Jun 24 |
1 |
| 3 |
26856397 | Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3. | 2016 Mar |
1 |
| 4 |
27064685 | Quantum Mechanics/Molecular Mechanics Modeling of Drug Metabolism: Mexiletine N-Hydroxylation by Cytochrome P450 1A2. | 2016 Jun 20 |
1 |
| 5 |
27428168 | Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy. | 2016 Oct |
2 |
| 6 |
27457784 | Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans. | 2016 Oct |
1 |
| 7 |
26218892 | Theoretical study on the N-demethylation mechanism of theobromine catalyzed by P450 isoenzyme 1A2. | 2015 Sep |
2 |
| 8 |
26276083 | Toxicokinetics of lefetamine and derived diphenylethylamine designer drugs-Contribution of human cytochrome P450 isozymes to their main phase I metabolic steps. | 2015 Nov 4 |
1 |
| 9 |
26456786 | Low resolution and high resolution MS for studies on the metabolism and toxicological detection of the new psychoactive substance methoxypiperamide (MeOP). | 2015 Oct |
1 |
| 10 |
24410629 | Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic? | 2014 Feb 17 |
4 |
| 11 |
24841887 | The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application. | 2014 Jul 15 |
2 |
| 12 |
23988488 | Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse. | 2013 Nov 15 |
1 |
| 13 |
22331994 | Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance. | 2012 May |
1 |
| 14 |
21081470 | Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. | 2011 Feb |
1 |
| 15 |
21816953 | Application of homology modeling to generate CYP1A1 mutants with enhanced activation of the cancer chemotherapeutic prodrug dacarbazine. | 2011 Nov |
1 |
| 16 |
21894985 | Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2. | 2011 Oct 12 |
2 |
| 17 |
20004212 | Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx). | 2010 Feb 3 |
2 |
| 18 |
20615392 | Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. | 2010 Oct 15 |
2 |
| 19 |
19904008 | Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study. | 2009 Sep-Oct |
1 |
| 20 |
18725511 | The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxy-methamphetamine and its enantiomers. | 2008 Nov |
1 |
| 21 |
17020955 | Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. | 2007 Jan |
1 |
| 22 |
17576805 | Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes. | 2007 Sep |
1 |
| 23 |
17951033 | Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. | 2007 Dec |
1 |
| 24 |
16272405 | Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. | 2006 Mar |
1 |
| 25 |
16988941 | CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl. | 2006 Dec 1 |
1 |
| 26 |
15944213 | The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo. | 2005 Nov |
1 |
| 27 |
16167840 | Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2. | 2005 Sep |
1 |
| 28 |
14729370 | Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes. | 2004 Feb 14 |
1 |
| 29 |
12519694 | Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates. | 2003 Jan |
1 |
| 30 |
12663521 | Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2. | 2003 Mar |
1 |
| 31 |
12721102 | Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. | 2003 Apr |
1 |
| 32 |
14531463 | Concentration dependent stereoselectivity of propafenone N-depropylation metabolism with human hepatic recombinant CYP1A2. | 2003 Sep |
2 |
| 33 |
11756232 | Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes. | 2002 Jan |
2 |
| 34 |
12016157 | Excretion of the N(2)-glucuronide conjugate of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in urine and its relationship to CYP1A2 and NAT2 activity levels in humans. | 2002 May |
2 |
| 35 |
12067565 | Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines. | 2002 Aug |
1 |
| 36 |
12180536 | The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. | 2002 Jul |
1 |
| 37 |
12487729 | Comparison of rat and human cytochrome P450 (CYP) sources of N-alkylprotoporphyrin IX. Formation after interaction with porphyrinogenic xenobiotics: studies with cDNA-expressed single CYP enzymes. | 2002 Nov |
1 |
| 38 |
11459203 | In vivo inhibition of human CYP1A2 activity by oltipraz. | 2001 Jun |
1 |
| 39 |
11504269 | Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations. | 2001 Aug |
1 |
| 40 |
10720722 | Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy'). | 2000 Mar 15 |
2 |
| 41 |
10837012 | Characterization of an ATP-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4, 5-f]quinoline. | 2000 Jun |
1 |
| 42 |
11013410 | Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay. | 2000 |
2 |
| 43 |
11136295 | Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. | 2000 Dec |
1 |
| 44 |
10199594 | Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. | 1999 Feb |
1 |
| 45 |
10359460 | Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine. | 1999 Apr 1 |
1 |
| 46 |
10460803 | Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. | 1999 Sep |
3 |
| 47 |
10473105 | Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. | 1999 Aug |
1 |
| 48 |
10537291 | N-oxidative metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in humans: excretion of the N2-glucuronide conjugate of 2-hydroxyamino-MeIQx in urine. | 1999 Oct 15 |
2 |
| 49 |
9581821 | Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines. | 1998 May 1 |
1 |
| 50 |
9084457 | Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4. | 1997 Mar |
2 |