Title : Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study.

Pub. Date : 2009 Sep-Oct

PMID : 19904008






1 Functional Relationships(s)
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1 The Dixon analysis showed that in both human liver microsomes and Supersomes CYP1A2 perazine potently and to a similar degree inhibited caffeine 3-N-demethylation (K(i) = 3.5 microM) and 1-N-demethylation (K(i) = 5 microM). Nitrogen cytochrome P450 family 1 subfamily A member 2 Homo sapiens